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06.05.2024 | Review Article

The effect of hyperoxia on muscle sympathetic nerve activity: a systematic review and meta-analysis

verfasst von: Desmond A. Young, Paris A. T. Jones, Brittany A. Matenchuk, Allison Sivak, Margie H. Davenport, Craig D. Steinback

Erschienen in: Clinical Autonomic Research | Ausgabe 2/2024

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Abstract

Purpose

We conducted a meta-analysis to determine the effect of hyperoxia on muscle sympathetic nerve activity in healthy individuals and those with cardio-metabolic diseases.

Methods

A comprehensive search of electronic databases was performed until August 2022. All study designs (except reviews) were included: population (humans; apparently healthy or with at least one chronic disease); exposures (muscle sympathetic nerve activity during hyperoxia or hyperbaria); comparators (hyperoxia or hyperbaria vs. normoxia); and outcomes (muscle sympathetic nerve activity, heart rate, blood pressure, minute ventilation). Forty-nine studies were ultimately included in the meta-analysis.

Results

In healthy individuals, hyperoxia had no effect on sympathetic burst frequency (mean difference [MD] − 1.07 bursts/min; 95% confidence interval [CI] − 2.17, 0.04bursts/min; P = 0.06), burst incidence (MD 0.27 bursts/100 heartbeats [hb]; 95% CI − 2.10, 2.64 bursts/100 hb; P = 0.82), burst amplitude (P = 0.85), or total activity (P = 0.31). In those with chronic diseases, hyperoxia decreased burst frequency (MD − 5.57 bursts/min; 95% CI − 7.48, − 3.67 bursts/min; P < 0.001) and burst incidence (MD − 4.44 bursts/100 hb; 95% CI − 7.94, − 0.94 bursts/100 hb; P = 0.01), but had no effect on burst amplitude (P = 0.36) or total activity (P = 0.90). Our meta-regression analyses identified an inverse relationship between normoxic burst frequency and change in burst frequency with hyperoxia. In both groups, hyperoxia decreased heart rate but had no effect on any measure of blood pressure.

Conclusion

Hyperoxia does not change sympathetic activity in healthy humans. Conversely, in those with chronic diseases, hyperoxia decreases sympathetic activity. Regardless of disease status, resting sympathetic burst frequency predicts the degree of change in burst frequency, with larger decreases for those with higher resting activity.

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Titel: The effect of hyperoxia on muscle sympathetic nerve activity: a systematic review and meta-analysis
verfasst von: Desmond A. Young
Paris A. T. Jones
Brittany A. Matenchuk
Allison Sivak
Margie H. Davenport
Craig D. Steinback
Publikationsdatum: 06.05.2024
Verlag: Springer Berlin Heidelberg
Erschienen in: Clinical Autonomic Research / Ausgabe 2/2024
Print ISSN: 0959-9851
Elektronische ISSN: 1619-1560
DOI: https://doi.org/10.1007/s10286-024-01033-4

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The effect of hyperoxia on muscle sympathetic nerve activity: a systematic review and meta-analysis