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01.02.2010 | CME Weiterbildung · Zertifizierte Fortbildung

Sport bei Krebspatienten

verfasst von: Prof. Dr. I.A. Adamietz

Erschienen in: Die Onkologie | Ausgabe 2/2010

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Zusammenfassung

Sport und körperliche Aktivität sind wirksame Maßnahmen der Gesundheitsförderung. Ihre Rolle bei Tumorpatienten wurde jedoch lange Zeit unterschätzt. Weltweit machen Lebensumstände etwa 50–75% des Krebsrisikos aus. Bei einer wachsenden Zahl von Malignomen ist Bewegungsmangel neben Adipositas und Fehlernährung von kritischer Bedeutung. Das Bindeglied zwischen Adipositas, Bewegungsmangel und Krebs stellen die insulinartigen Wachstumsfaktoren dar, die evtl. für die Entwicklung einer endokrinen Therapieresistenz mitverantwortlich sind. Die Beeinflussung des Glukose- und Insulinstoffwechsels entwickelt sich deshalb zu einer neuen und ergänzenden Strategie gegen malignes Zellwachstum. Darüber hinaus zeigten zahlreiche Untersuchungen, dass regelmäßige körperliche Aktivität bei Tumorpatienten nicht nur zu einer Verbesserung der körperlichen Leistungsfähigkeit, sondern auch zu einer Reduktion der Nebenwirkungen der Therapie (v. a. der Fatigue), einer Stimmungsaufhellung und einer Zunahme der Lebensqualität führt.

Adamsen L, Quist M, Midtgaard J et al (2006) The effect of a multidimensional exercise intervention on physical capacity, well-being and quality of life in cancer patients undergoing chemotherapy. Support Care Cancer 14:116–127CrossRefPubMed

Ainsworth BE, Haskell WL, Leon AS et al (1993) Compendium of physical activities: classification of energy costs of human physical activities. Med Sci Sports Exerc 25:71–80CrossRefPubMed

Ainsworth BE, Haskell WL, Whitt MC et al (2000) Compendium of physical activities: an update of activity codes and MET intensities. Med Sci Sports Exerc [Suppl 9] 32:S498–S504

Al-Majid S, Waters H (2008) The biological mechanisms of cancer-related skeletal muscle wasting: the role of progressive resistance exercise. Biol Res Nurs 10:7–20CrossRefPubMed

Basen-Engquist K, Hughes D, Perkins H et al (2008) Dimensions of physical activity and their relationship to physical and emotional symptoms in breast cancer survivors. J Cancer Surviv 2:253–261CrossRefPubMed

Caan BJ, Emond JA, Natarajan L et al (2006) Post-diagnosis weight gain and breast cancer recurrence in women with early stage breast cancer. Breast Cancer Res Treat 99:47–57CrossRefPubMed

Calle EE, Rodriguez C, Walker-Thurmond K et al (2003) Overweight, obesity, and mortality from cancer in a prospectively studied cohort of U.S. adults. N Engl J Med 348:1625–1638CrossRefPubMed

Carlson LE, Smith D, Russell J et al (2006) Individualized exercise program for the treatment of severe fatigue in patients after allogeneic hematopoietic stem-cell transplant: a pilot study. Bone Marrow Transplant 37:945–954CrossRefPubMed

Carpenter CL, Ross RK, Paganini-Hill A et al (2003) Effect of family history, obesity and exercise on breast cancer risk among postmenopausal women. Int J Cancer 106:96–102CrossRefPubMed

10.

Colbert LH, Hartman TJ, Tangrea JA et al (2002) Physical activity and lung cancer risk in male smokers. Int J Cancer 98:770–773CrossRefPubMed

11.

Courneya KS, Friedenreich CM, Quinney HA et al (2003) A randomized trial of exercise and quality of life in colorectal cancer survivors. Eur J Cancer Care (Engl) 12:347–357

12.

Courneya KS, Mackey JR, Bell GJ et al (2003) Randomized controlled trial of exercise training in postmenopausal breast cancer survivors: cardiopulmonary and quality of life outcomes. J Clin Oncol 21:1660–1668CrossRefPubMed

13.

Courneya KS, Segal RJ, Mackey JR et al (2007) Effects of aerobic and resistance exercise in breast cancer patients receiving adjuvant chemotherapy: a multicenter randomized controlled trial. J Clin Oncol 25(28):4396–4404CrossRefPubMed

14.

Coyle YM (2008) Physical activity as a negative modulator of estrogen-induced breast cancer. Cancer Causes Control 19:1021–1029CrossRefPubMed

15.

Daley AJ, Crank H, Saxton JM et al (2007) Randomized trial of exercise therapy in women treated for breast cancer. J Clin Oncol 25:1713–1721CrossRefPubMed

16.

Dimeo FC (2001) Effects of exercise on cancer-related fatigue. Cancer 92:1689–1693CrossRefPubMed

17.

Dimeo FC (2001) Körperliche Aktivität und Krebs: Eine Übersicht. Dtsch Z Sportmed 52:238–244

18.

Dimeo F (2004) Standards in der Sportmedizin: Körperliche Aktivität und Krebs. Dtsch Z Sportmed 4:106–107

19.

Dimeo FC, Thiel E (2008) Körperliche Aktivität und Sport bei Krebspatienten. Onkologe 14:31–37CrossRef

20.

Dimeo F, Fetscher S, Lange W et al (1997) Effects of aerobic exercise on the physical performance and incidence of treatment-related complications after high-dose chemotherapy. Blood 90:3390–3394PubMed

21.

Dimeo F, Tilmann MH, Bertz H et al (1997) Aerobic exercise in the rehabilitation of cancer patients after high dose chemotherapy and autologous peripheral stem cell transplantation. Cancer 79:1717–1722CrossRefPubMed

22.

Dimeo F, Rumberger BG, Keul J (1998) Aerobic exercise as therapy for cancer fatigue. Med Sci Sports Exerc 30:475–478PubMed

23.

Dimeo F, Stieglitz RD, Novelli-Fischer U et al (1999) Effects of physical activity on the fatigue and psychologic status of cancer patients during chemotherapy. Cancer 85:2273–2277CrossRefPubMed

24.

Dimeo F, Schwartz S, Fietz T et al (2003) Effects of endurance training on the physical performance of patients with hematological malignancies during chemotherapy. Support Care Cancer 11:623–628CrossRefPubMed

25.

Dimeo FC, Thomas F, Raabe-Menssen C et al (2004) Effect of aerobic exercise and relaxation training on fatigue and physical performance of cancer patients after surgery. A randomised controlled trial. Support Care Cancer 12:774–779CrossRefPubMed

26.

Fairey AS, Courneya KS, Field CJ et al (2003) Effects of exercise training on fasting insulin, insulin resistance, insulin-like growth factors, and insulin-like growth factor binding proteins in postmenopausal breast cancer survivors: a randomized controlled trial. Cancer Epidemiol Biomarkers Prev 12:721–727PubMed

27.

Fasching PA, Hübner J, Kleeberg UR (2009) Körperliche Bewegung und Sport zur Prävention und Behandlung von Krebskrankheiten. Onkologe 15:696–701CrossRef

28.

Gilliland FD, Li YF, Baumgartner K et al (2001) Physical activity and breast cancer risk in Hispanic and non-Hispanic white women. Am J Epidemiol 154:442–450CrossRefPubMed

29.

Haydon AM, Macinnis RJ, English DR et al (2006) Effect of physical activity and body size on survival after diagnosis with colorectal cancer. Gut 55:62–67CrossRefPubMed

30.

Heitkamp HC, Bott M (2001) Kolorektalkarzinome und körperliche Aktivität. Dtsch Ärztebl 10:A612–A618

31.

Hoffman-Goetz L, May KM, Arumugam Y (1994) Exercise training and mouse mammary tumour metastasis. Anticancer Res 14:2627–2631PubMed

32.

Holmes MD, Chen WY, Feskanich D et al (2005) Physical activity and survival after breast cancer diagnosis. JAMA 293:2479–2486CrossRefPubMed

33.

Hsieh CC, Sprod LK, Hydock DS et al (2008) Effects of a supervised exercise intervention on recovery from treatment regimens in breast cancer survivors. Oncol Nurs Forum 35:909–915CrossRefPubMed

34.

Irwin ML, McTiernan A, Bernstein L et al (2005) Relationship of obesity and physical activity with C-peptide, leptin and insulin-like growth factors in breast cancer survivors. Cancer Epidemiol Biomarkers Prev 14:2881–2888CrossRefPubMed

35.

Irwin ML, Varma K, Alvarez-Reeves M et al (2009) Randomized controlled trial of aerobic exercise on insulin and insulin-like growth factors in breast cancer survivors: the Yale exercise and survivorship study. Cancer Epidemiol Biomarkers Prev 18:306–313CrossRefPubMed

36.

Leitzmann MF, Ahn J, Albanes D et al (2008) Diabetes mellitus and prostate cancer risk in the prostate, lung, colorectal and ovarian cancer screening trial. Cancer Causes Control 19:1267–1276CrossRefPubMed

37.

Ligibel JA, Campbell N, Partridge A et al (2008) Impact of a mixed strength and endurance exercise intervention on insulin levels in breast cancer survivors. J Clin Oncol 26:907–912CrossRefPubMed

38.

MacVicar MG, Winningham ML, Nickel JL (1989) Effects of aerobic interval training on cancer patients‘ functional capacity. Nurs Res 38:348–351CrossRefPubMed

39.

Meyerhardt JA, Tepper JE, Niedzwiecki D et al (2004) Impact of body mass index on outcomes and treatment-related toxicity in patients with stage II and III rectal cancer: findings from intergroup trial 0114. J Clin Oncol 22:648–657CrossRefPubMed

40.

Milne HM, Wallman KE, Gordon S, Courneya KS (2007) Effects of a combined aerobic and resistance exercise program in breast cancer survivors: a randomized controlled trial. Breast Cancer Res Treat 108(2):279–288. doi: 10.1007/s10549-007-9602-zCrossRefPubMed

41.

Mock V, Barton B, Sheehan P et al (1994) A nursing rehabilitation program for women with breast cancer receiving adjuvant chemotherapy. Oncol Nurs Forum 21:899–907PubMed

42.

Mock V, Dow KH, Meares CJ et al (1997) Effects of exercise on fatigue, physical functioning and emotional distress during radiation therapy for breast cancer. Oncol Nurs Forum 24:991–1000PubMed

43.

Ohira T, Schmitz KH, Ahmed RL, Yee D (2006) Effects of weight training on quality of life in recent breast cancer survivors: the weight training for breast cancer survivors (WTBS) study. Cancer 106:2076–2083CrossRefPubMed

44.

Olson JE, Yang P, Schmitz K et al (2002) Differential association of body mass index and fat distribution with three major histologic types of lung cancer: evidence from a cohort of older women. Am J Epidemiol 156:606–615CrossRefPubMed

45.

Orsini N, Mantzoros CS, Wolk A (2008) Association of physical activity with cancer incidence, mortality and survival: a population-based study of men. Br J Cancer 98:1864–1869CrossRefPubMed

46.

Pan SY, DesMeules M (2009) Energy intake, physical activity, energy balance and cancer: epidemiologic evidence. Methods Mol Biol 472:191–215CrossRefPubMed

47.

Patel AV, Feigelson HS, Talbot JT et al (2008) The role of body weight in the relationship between physical activity and endometrial cancer: results from a large cohort of US women. Int J Cancer 123:1877–1882CrossRefPubMed

48.

Porock D, Kristjanson LJ, Tinnelly K et al (2000) An exercise intervention for advanced cancer patients experiencing fatigue: a pilot study. J Palliat Care 16:30–36PubMed

49.

Salazar-Martinez E, Lazcano-Ponce EC, Lira-Lira GG et al (2000) Case-control study of diabetes, obesity, physical activity and risk of endometrial cancer among Mexican women. Cancer Causes Control 11:707–711CrossRefPubMed

50.

Schmidt ME, Steindorf K, Mutschelknauss E et al (2008) Physical activity and postmenopausal breast cancer: effect modification by breast cancer subtypes and effective periods in life. Cancer Epidemiol Biomarkers Prev 17:3402–3410CrossRefPubMed

51.

Schmitz KH, Ahmed RL, Hannan PJ et al (2005) Safety and efficacy of weight training in recent breast cancer survivors to alter body composition, insulin, and insulin-like growth factor axis proteins. Cancer Epidemiol Biomarkers Prev 14:1672–1680CrossRefPubMed

52.

Schmitz KH, Ahmed RL, Yee D (2002) Effects of a 9-month strength training intervention on insulin, insulin-like growth factor (IGF)-I, IGF-binding protein (IGFBP)-1, and IGFBP-3 in 30–50-year-old women. Cancer Epidemiol Biomarkers Prev 11:1597–1604PubMed

53.

Schnohr P, Gronbaek M, Petersen L et al (2005) Physical activity in leisure-time and risk of cancer: 14-year follow-up of 28,000 Danish men and women. Scand J Public Health 33:244–249CrossRefPubMed

54.

Schwartz AL (2000) Exercise and weight gain in breast cancer patients receiving chemotherapy. Cancer Pract 8:231–237CrossRefPubMed

55.

Schwartz AL, Mori M, Gao R (2001) Exercise reduces daily fatigue in women with breast cancer receiving chemotherapy. Med Sci Sports Exerc 33:718–723CrossRefPubMed

56.

Schwartz AL, Thompson JA, Masood N (2002) Interferon-induced fatigue in patients with melanoma: a pilot study of exercise and methylphenidate. Oncol Nurs Forum 29:E85–E90CrossRefPubMed

57.

Segal R, Evans W, Johnson D et al (2001) Structured exercise improves physical functioning in women with stages I and II breast cancer: results of a randomized controlled trial. J Clin Oncol 19:657–665PubMed

58.

Segal RJ, Reid RD, Courneya KS et al (2003) Resistance exercise in men receiving androgen deprivation therapy for prostate cancer. J Clin Oncol 21:1653–1659CrossRefPubMed

59.

Simoes EJ, Byers T, Coates RJ et al (1995) The association between leisure-time physical activity and dietary fat in American adults. Am J Public Health 85:240–244CrossRefPubMed

60.

Smets EMA, Garssen B, Schuster-Uitterhoeve ALJ, Haes JCJM de (1993) Fatigue in cancer patients. Br J Cancer 68:220–224PubMed

61.

Thune I, Lund E (1996) Physical activity and risk of colorectal cancer in men and women. Br J Cancer 73:1134–1140PubMed

62.

Torti DC, Matheson GO (2004) Exercise and prostate cancer. Sports Med 34:363–369CrossRefPubMed

63.

Trentham-Dietz A, Nichols HB, Hampton JM et al (2006) Weight change and risk of endometrial cancer. Int J Epidemiol 35:151–158CrossRefPubMed

64.

Wannamethee SG, Shaper AG, Walker M (2001) Physical activity and risk of cancer in middle-aged men. Br J Cancer 85:1311–1316CrossRefPubMed

65.

World Cancer Research Fund International (WCRFI), American Institute of Cancer Research, Deutsches Institut für Ernährungsforschung (DIfE) et al (2003) Krebsprävention durch Ernährung. Forschung, Daten, Begründungen, Empfehlungen. Eigenverlag, Potsdam-Rehbrücke

66.

Zeegers MP, Dirx MJ, Van den Brandt PA (2005) Physical activity and the risk of prostate cancer in the Netherlands cohort study, results after 9.3 years of follow-up. Cancer Epidemiol Biomarkers Prev 14:1490–1495CrossRefPubMed

67.

Zheng X, Cui XX, Huang MT et al (2008) Inhibitory effect of voluntary running wheel exercise on the growth of human pancreatic Panc-1 and prostate PC-3 xenograft tumors in immunodeficient mice. Oncol Rep 19:1583–1588PubMed

Titel: Sport bei Krebspatienten
verfasst von: Prof. Dr. I.A. Adamietz
Publikationsdatum: 01.02.2010
Verlag: Springer-Verlag
Erschienen in: Die Onkologie / Ausgabe 2/2010
Print ISSN: 2731-7226
Elektronische ISSN: 2731-7234
DOI: https://doi.org/10.1007/s00761-009-1780-3

Springer Medizin

Sport bei Krebspatienten

Zusammenfassung

Neu im Fachgebiet Onkologie

Labor, CT-Anthropometrie zeigen Risiko für Pankreaskrebs

Viel pflanzliche Nahrung, seltener Prostata-Ca.-Progression

Alter verschlechtert Prognose bei Endometriumkarzinom

Darf man die Behandlung eines Neonazis ablehnen?

Update Onkologie

Springer Medizin

Zusammenfassung

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