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2022 | Multiple Sklerose | OriginalPaper | Buchkapitel

23. Multiple Sklerose

verfasst von : Prof. Dr. med. Roland Seifert, Prof. Dr. med. Friedemann Paul

Erschienen in: Arzneiverordnungs-Report 2022

Verlag: Springer Berlin Heidelberg

Zusammenfassung

Auf einen Blick

Spektrum Zur Behandlung der multiplen Sklerose werden krankheitsmodifizierende Immuntherapeutika und symptomatisch wirkende Arzneistoffe eingesetzt. Die Verordnung von Beta-Interferonen für die Behandlung der schubförmig-remittierenden multiplen Sklerose geht seit Jahren zu Gunsten anderer Arzneistoffe (insbesondere Dimethylfumarat, Glatirameracetat, Teriflunomid, Ocrelizumab und Natalizumab) zurück. Den stärksten Verordnungsschub verzeichnete Siponimod.
Als Muskelrelaxanzien (Antispastika) stehen Baclofen, Tizanidin und Botulinumtoxin bei der symptomatischen Behandlung der multiplen Sklerose im Vordergrund. Die Verordnungszahlen für das Cannabinoidpräparat Nabiximols sind deutlich angestiegen. Erstaunlicherweise wurden auch Muskelrelaxanzien mit unzureichender Beleglage (z. B. Chininsulfat, Methocarbamol, Pridinol) wie auch schon 2021 deutlich häufiger verordnet. Dies ist unter dem Aspekt der evidenzbasierten Medizin nicht nachvollziehbar und sehr kritikwürdig.
Kosten Der weitaus größte Teil der Kosten entfällt auf die Immuntherapeutika.
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Zurück zum Zitat Henze T, Feneberg W, Flachenecker P, Seidel D, Albrecht H, Starck M, Meuth SG (2017) Neues zur symptomatischen MS‑Therapie: Teil 2 – Gangstörung und Spastik. Nervenarzt 88:1428–1434PubMed Henze T, Feneberg W, Flachenecker P, Seidel D, Albrecht H, Starck M, Meuth SG (2017) Neues zur symptomatischen MS‑Therapie: Teil 2 – Gangstörung und Spastik. Nervenarzt 88:1428–1434PubMed
Zurück zum Zitat Herzog S, Shanahan M, Grimison P, Tran A, Wong N, Lintzeris N, Simes J, Stockler M, Morton RL (2018) Systematic review of the costs and benefits of prescribed cannabis-based medicines for the management of chronic illness: Lessons from multiple sclerosis. PharmacoEconomics 36:67–78PubMed Herzog S, Shanahan M, Grimison P, Tran A, Wong N, Lintzeris N, Simes J, Stockler M, Morton RL (2018) Systematic review of the costs and benefits of prescribed cannabis-based medicines for the management of chronic illness: Lessons from multiple sclerosis. PharmacoEconomics 36:67–78PubMed
Zurück zum Zitat Huisman E, Papadimitropoulou K, Jarrett J, Bending M, Firth Z, Allen F, Adlard N (2017) Systematic literature review and network meta-analysis in highly active relapsing-remitting multiple sclerosis and rapidly evolving severe multiple sclerosis. BMJ Open 7:e13430 Huisman E, Papadimitropoulou K, Jarrett J, Bending M, Firth Z, Allen F, Adlard N (2017) Systematic literature review and network meta-analysis in highly active relapsing-remitting multiple sclerosis and rapidly evolving severe multiple sclerosis. BMJ Open 7:e13430
Zurück zum Zitat Hupperts R, Lycke J, Short C, Gasperini C, McNeill M, Medori R, Tofil-Kaluza A, Hovenden M, Mehta LR, Elkins J (2016) Prolonged-release fampridine and walking and balance in MS: randomised controlled MOBILE trial. Mult Scler 22:212–221PubMedPubMedCentral Hupperts R, Lycke J, Short C, Gasperini C, McNeill M, Medori R, Tofil-Kaluza A, Hovenden M, Mehta LR, Elkins J (2016) Prolonged-release fampridine and walking and balance in MS: randomised controlled MOBILE trial. Mult Scler 22:212–221PubMedPubMedCentral
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Zurück zum Zitat Naismith RT, Wundes A, Ziemssen T et al (2020) Diroximel fumarate demonstrates an improved gastrointestinal tolerability profile compared with dimethyl fumarate in patients with relapsing-remitting multiple sclerosis: Results from the randomized, double-blind, phase III EVOLVE-MS-2 study. CNS Drugs 34:185–196PubMedPubMedCentral Naismith RT, Wundes A, Ziemssen T et al (2020) Diroximel fumarate demonstrates an improved gastrointestinal tolerability profile compared with dimethyl fumarate in patients with relapsing-remitting multiple sclerosis: Results from the randomized, double-blind, phase III EVOLVE-MS-2 study. CNS Drugs 34:185–196PubMedPubMedCentral
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Zurück zum Zitat Novotna A, Mares J, Ratcliffe S, Novakova I, Vachova M, Zapletalova O, Gasperini C, Pozzilli C, Cefaro L, Comi G, Rossi P, Ambler Z, Stelmasiak Z, Erdmann A, Montalban X, Klimek A, Davies P, Sativex Spasticity Study Group (2011) A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis. Eur J Neurol 18:1122–1131PubMed Novotna A, Mares J, Ratcliffe S, Novakova I, Vachova M, Zapletalova O, Gasperini C, Pozzilli C, Cefaro L, Comi G, Rossi P, Ambler Z, Stelmasiak Z, Erdmann A, Montalban X, Klimek A, Davies P, Sativex Spasticity Study Group (2011) A randomized, double-blind, placebo-controlled, parallel-group, enriched-design study of nabiximols* (Sativex(®) ), as add-on therapy, in subjects with refractory spasticity caused by multiple sclerosis. Eur J Neurol 18:1122–1131PubMed
Zurück zum Zitat O’Connor P, Comi G, Freedman MS, Miller AE, Kappos L, Bouchard JP, Lebrun-Frenay C, Mares J, Benamor M, Thangavelu K, Liang J, Truffinet P, Lawson VJ, Wolinsky JS, Teriflunomide Multiple Sclerosis Oral (TEMSO) Trial Group and the MRI-AC in Houston (2016) Long-term safety and efficacy of teriflunomide: Nine-year follow-up of the randomized TEMSO study. Baillieres Clin Neurol 86:920–930 O’Connor P, Comi G, Freedman MS, Miller AE, Kappos L, Bouchard JP, Lebrun-Frenay C, Mares J, Benamor M, Thangavelu K, Liang J, Truffinet P, Lawson VJ, Wolinsky JS, Teriflunomide Multiple Sclerosis Oral (TEMSO) Trial Group and the MRI-AC in Houston (2016) Long-term safety and efficacy of teriflunomide: Nine-year follow-up of the randomized TEMSO study. Baillieres Clin Neurol 86:920–930
Zurück zum Zitat Otero-Romero S, Sastre-Garriga J, Comi G, Hartung HP, Soelberg Sørensen P, Thompson AJ, Vermersch P, Gold R, Montalban X (2016) Pharmacological management of spasticity in multiple sclerosis: systematic review and consensus paper. Mult Scler 22:1386–1396PubMed Otero-Romero S, Sastre-Garriga J, Comi G, Hartung HP, Soelberg Sørensen P, Thompson AJ, Vermersch P, Gold R, Montalban X (2016) Pharmacological management of spasticity in multiple sclerosis: systematic review and consensus paper. Mult Scler 22:1386–1396PubMed
Zurück zum Zitat Pengo M, Miante S, Franciotta S, Ponzano M, Torresin T, Bovis F, Rinaldi F, Perini P, Saiani M, Margoni M, Bertoldo A, Sormani MP, Pilotto E, Midena E, Gallo P, Puthenparampil M (2022) Retina hyperreflecting foci associate with cortical pathology in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 9:e1180PubMedPubMedCentral Pengo M, Miante S, Franciotta S, Ponzano M, Torresin T, Bovis F, Rinaldi F, Perini P, Saiani M, Margoni M, Bertoldo A, Sormani MP, Pilotto E, Midena E, Gallo P, Puthenparampil M (2022) Retina hyperreflecting foci associate with cortical pathology in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 9:e1180PubMedPubMedCentral
Zurück zum Zitat Perriguey M, Maarouf A, Stellmann JP, Rico A, Boutiere C, Demortiere S, Durozard P, Pelletier J, Audoin B (2021) Hypogammaglobulinemia and infections in patients with multiple sclerosis treated with rituximab. Neurol Neuroimmunol Neuroinflamm 9:e1115PubMedPubMedCentral Perriguey M, Maarouf A, Stellmann JP, Rico A, Boutiere C, Demortiere S, Durozard P, Pelletier J, Audoin B (2021) Hypogammaglobulinemia and infections in patients with multiple sclerosis treated with rituximab. Neurol Neuroimmunol Neuroinflamm 9:e1115PubMedPubMedCentral
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Zurück zum Zitat Rasche L, Paul F (2018) Ozanimod for the treatment of relapsing remitting multiple sclerosis. Expert Opin Pharmacother 19:2073–2086PubMed Rasche L, Paul F (2018) Ozanimod for the treatment of relapsing remitting multiple sclerosis. Expert Opin Pharmacother 19:2073–2086PubMed
Zurück zum Zitat Roodselaar J, Zhou Y, Leppert D, Hauser AE, Urich E, Anthony DC (2021) Anti-CD20 disrupts meningeal B-cell aggregates in a model of secondary progressive multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 8:e975PubMedPubMedCentral Roodselaar J, Zhou Y, Leppert D, Hauser AE, Urich E, Anthony DC (2021) Anti-CD20 disrupts meningeal B-cell aggregates in a model of secondary progressive multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 8:e975PubMedPubMedCentral
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Zurück zum Zitat Von Essen MR, Hansen RH, Hojgaard C, Ammitzboll C, Wiendl H, Sellebjerg F (2022) Ofatumumab modulates inflammatory T cell responses and migratory potential in patients with multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 9:e200004 Von Essen MR, Hansen RH, Hojgaard C, Ammitzboll C, Wiendl H, Sellebjerg F (2022) Ofatumumab modulates inflammatory T cell responses and migratory potential in patients with multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 9:e200004
Zurück zum Zitat Zhovtis Ryerson L, Naismith RT, Krupp LB, Charvet LE, Liao S, Fisher E, de Moor C, Williams JR, Campbell N (2022) No difference in radiologic outcomes for natalizumab patients treated with extended interval dosing compared with standard interval dosing: real-world evidence from MS PATHS. Mult Scler Relat Disord 58:103480 Zhovtis Ryerson L, Naismith RT, Krupp LB, Charvet LE, Liao S, Fisher E, de Moor C, Williams JR, Campbell N (2022) No difference in radiologic outcomes for natalizumab patients treated with extended interval dosing compared with standard interval dosing: real-world evidence from MS PATHS. Mult Scler Relat Disord 58:103480
Zurück zum Zitat Zinger N, Ponath G, Sweeney E, Nguyen TD, Lo CH, Diaz I, Dimov A, Teng L, Zexter L, Comunale J, Wang Y, Pitt D, Gauthier SA (2022) Dimethyl fumarate reduces inflammation in chronic active multiple sclerosis lesions. Neurol Neuroimmunol Neuroinflamm 9:e1138PubMedPubMedCentral Zinger N, Ponath G, Sweeney E, Nguyen TD, Lo CH, Diaz I, Dimov A, Teng L, Zexter L, Comunale J, Wang Y, Pitt D, Gauthier SA (2022) Dimethyl fumarate reduces inflammation in chronic active multiple sclerosis lesions. Neurol Neuroimmunol Neuroinflamm 9:e1138PubMedPubMedCentral
Metadaten
Titel
Multiple Sklerose
verfasst von
Prof. Dr. med. Roland Seifert
Prof. Dr. med. Friedemann Paul
Copyright-Jahr
2022
Verlag
Springer Berlin Heidelberg
DOI
https://doi.org/10.1007/978-3-662-66303-5_23

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