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International Ophthalmology

Erschienen in:

12.06.2023 | Original Paper

Dexpanthenol/sodium hyaluronate eye drops for corneal epithelial healing following corneal cross-linking in patients with keratoconus

verfasst von: Huri Sabur, Mutlu Acar

Erschienen in: International Ophthalmology | Ausgabe 10/2023

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Abstract

Purpose

To evaluate the effect of dexpanthenol 2%/sodium hyaluronate 0.15% eye drops on corneal epithelial healing and corneal microstructural changes following corneal cross-linking (CXL) in patients with keratoconus.

Methods

The study included 42 eyes of 21 patients with keratoconus who underwent CXL on both eyes. One eye of each patient was instilled dexpanthenol 2%/sodium hyaluronate 0.15% eye drops (DP/SH group) and the fellow eye was instilled unpreserved sodium hyaluronate 0.15% eye drops (SH group). The epithelial healing process was assessed every day until complete reepithelialization was achieved. The in vivo confocal microscopy (IVCM) findings were also recorded.

Results

The mean epithelial defect size 48.6 ± 6.7 mm² for the DP/SH group and 48.2 ± 5.3 mm² for the SH group. Complete reepithelialization was seen after 2.24 ± 0.44 days (range 2–4 days) in the DP/SH group and 3.43 ± 0.60 days (3 to 5 days) in the SH group. Posterior keratocyte density and endothelial cell density were similar in both groups. The mean subbasal nerve plexus density was significantly higher in the DP/SH group (postoperative 1 month: 1.13 ± 1.51, 3 months: 3.53 ± 2.55, 6 months: 7.07 ± 1.42) compared to the SH group (postoperative 1 month: 0.87 ± 1.43, 3 months: 2.89 ± 2.62, 6 months 6.33 ± 1.29). The DP/SH group revealed faster subbasal nerve regeneration and less edema compared to the SH group.

Conclusion

Dexpanthenol 2%/sodium hyaluronate 0.15% eye drops were effective and safe for corneal epithelial healing, and promoted faster corneal reepithelialization, nerve regeneration, and keratocyte repopulation with reduced corneal edema compared to sodium hyaluronate eye drops.

Feder RS, Kshettry P (2005) Noninflammatory ectatic disorders. In: Krachmer JH, Mannis MJ, Holland EJ (eds) Cornea. Elsevier-Mosby, Philadelphia, pp 955–974

Romero-Jiménez M, Santodomingo-Rubido J, Wolffsohn JS (2010) Keratoconus: a review. Contact Lens Anterior Eye 33:157–166. https://doi.org/10.1016/j.clae.2010.04.006CrossRefPubMed

Mas Tur V, MacGregor C, Jayaswal R, O’Brart D, Maycock N (2017) A review of keratoconus: diagnosis, pathophysiology, and genetics. Surv Ophthalmol 62:770–783. https://doi.org/10.1016/j.survophthal.2017.06.009CrossRefPubMed

Saad S, Saad R, Jouve L, Kallel S, Trinh L, Goemaere I, Borderie V, Bouheraoua N (2020) Corneal crosslinking in keratoconus management. J Fr Ophtalmol 43:1078–1095. https://doi.org/10.1016/j.jfo.2020.07.002CrossRefPubMed

Wollensak G, Spoerl E, Seiler T (2003) Riboflavin/ultraviolet-a-induced collagen crosslinking for the treatment of keratoconus. Am J Ophthalmol 135:620–627. https://doi.org/10.1016/s0002-9394(02)02220-1CrossRefPubMed

Seiler TG, Schmidinger G, Fischinger I, Koller T, Seiler T (2013) Komplikationen der Vernetzung der Hornhaut [complications of corneal cross-linking]. Ophthalmologe 110:639–644. https://doi.org/10.1007/s00347-012-2682-0CrossRefPubMed

Ozek D, Kemer OE (2018) Effect of the bioprotectant agent trehalose on corneal epithelial healing after corneal cross-linking for keratoconus. Arq Bras Oftalmol 81:505–509. https://doi.org/10.5935/0004-2749.20180100CrossRefPubMed

Ondes Yilmaz F, Kepez Yildiz B, Tunc U, Kandemir Besek N, Yildirim Y, Demirok A (2021) Comparison of topical omega-3 fatty acids with topical sodium hyaluronate after corneal crosslinking: short term results. Ocul Immunol Inflamm 9:1–7. https://doi.org/10.1080/09273948.2020.1858117CrossRef

Kymionis GD, Liakopoulos DA, Grentzelos MA, Tsoulnaras KI, Detorakis ET, Cochener B, Tsilimbaris MK (2015) Effect of the regenerative agent poly (carboxymethylglucose sulfate) on corneal wound healing after corneal cross-linking for keratoconus. Cornea 34:928–931. https://doi.org/10.1097/ico.0000000000000484CrossRefPubMed

10.

Bata AM, Witkowska KJ, Wozniak PA, Fondi K, Schmidinger G, Pircher N, Szegedi S, Aranha Dos Santos V, Pantalon A, Werkmeister RM, Garhofer G, Schmetterer L, Schmidl D (2016) Effect of a matrix therapy agent on corneal epithelial healing after standard collagen cross-linking in patients with keratoconus: a randomized clinical trial. JAMA Ophthalmol 134:1169–1176. https://doi.org/10.1001/jamaophthalmol.2016.3019CrossRefPubMed

11.

Baumeister M, Bühren J, Ohrloff C, Kohnen T (2009) Corneal re-epithelialization following phototherapeutic keratectomy for recurrent corneal erosion as in vivo model of epithelial wound healing. Ophthalmologica 223:414–418. https://doi.org/10.1159/000230880CrossRefPubMed

12.

Proksch E, de Bony R, Trapp S, Boudon S (2017) Topical use of dexpanthenol: a 70th anniversary article. J Dermatol Treat 28:766–773. https://doi.org/10.1080/09546634.2017.1325310CrossRef

13.

Brown SE, Simmasalam R, Antonova N, Gadaria N, Asbell PA (2014) Progression in keratoconus and the effect of corneal cross-linking on progression. Eye Contact Lens 40:331–338. https://doi.org/10.1097/icl.0000000000000085CrossRefPubMed

14.

Hersh PS, Greenstein SA, Fry KL (2011) Corneal collagen crosslinking for keratoconus and corneal ectasia: one-year results. J Cataract Refract Surg 37:149–160. https://doi.org/10.1016/j.jcrs.2010.07.030CrossRefPubMed

15.

Gain P, Jullienne R, He Z, Aldossary M, Acquart S, Cognasse F, Thuret G (2016) Global survey of corneal transplantation and eye banking. JAMA Ophthalmol 134:167–173. https://doi.org/10.1001/jamaophthalmol.2015.4776CrossRefPubMed

16.

Kobashi H, Rong SS, Ciolino JB (2018) Transepithelial versus epithelium-off corneal crosslinking for corneal ectasia. J Cataract Refract Surg 44:1507–1516. https://doi.org/10.1016/j.jcrs.2018.08.021CrossRefPubMedPubMedCentral

17.

Bikbova G, Bikbov M (2016) Standard corneal collagen crosslinking versus transepithelial iontophoresis-assisted corneal crosslinking, 24 months follow-up: randomized control trial. Acta Ophthalmol 94:e600–e606. https://doi.org/10.1111/aos.13032CrossRefPubMedPubMedCentral

18.

Taneri S, Oehler S (2015) Komplikationen nach Hornhautquervernetzung [complications after corneal cross-linking]. Klin Monbl Augenheilkd 232:51–60. https://doi.org/10.1055/s-0034-1382963CrossRefPubMed

19.

Carlson E, Kao WWY, Ogundele A (2018) Impact of hyaluronic acid-containing artificial tear products on reepithelialization in an in vivo corneal wound model. J Ocul Pharmacol Ther 34:360–364. https://doi.org/10.1089/jop.2017.0080CrossRefPubMedPubMedCentral

20.

Bonzano C, Cutolo CA, Musetti D, Di Mola I, Pizzorno C, Scotto R, Traverso CE (2021) Delayed re-epithelialization after epithelium-off crosslinking: predictors and ımpact on keratoconus progression. Front Med (Lausanne) 8:657993. https://doi.org/10.3389/fmed.2021.657993CrossRefPubMed

21.

Vinciguerra P, Albè E, Trazza S, Seiler T, Epstein D (2009) Intraoperative and postoperative effects of corneal collagen cross-linking on progressive keratoconus. Arch Ophthalmol 127:1258–1265. https://doi.org/10.1001/archophthalmol.2009.205CrossRefPubMed

22.

Hamdi IM (2018) Effect of D-Panthenol on corneal epithelial healing after surface laser ablation. J Ophthalmol 2018:6537413. https://doi.org/10.1155/2018/6537413CrossRefPubMedPubMedCentral

23.

Mazzotta C, Caporossi T, Denaro R, Bovone C, Sparano C, Paradiso A, Baiocchi S, Caporossi A (2012) Morphological and functional correlations in riboflavin UV a corneal collagen cross-linking for keratoconus. Acta Ophthalmol 90:259–265. https://doi.org/10.1111/j.1755-3768.2010.01890.xCrossRefPubMed

24.

Zare MA, Mazloumi M, Farajipour H, Hoseini B, Fallah MR, Mahrjerdi HZ, Abtahi MA, Abtahi SH (2016) Effects of corneal collagen crosslinking on confocal microscopic findings and tear indices in patients with progressive keratoconus. Int J Prev Med 7:132. https://doi.org/10.4103/2008-7802.196527CrossRefPubMedPubMedCentral

25.

Mazzotta C, Balestrazzi A, Traversi C, Baiocchi S, Caporossi T, Tommasi C, Caporossi A (2007) Treatment of progressive keratoconus by riboflavin-UVA-induced cross-linking of corneal collagen: ultrastructural analysis by heidelberg retinal tomograph II in vivo confocal microscopy in humans. Cornea 26:390–397. https://doi.org/10.1097/ico.0b013e318030df5aCrossRefPubMed

26.

Mazzotta C, Traversi C, Baiocchi S, Caporossi O, Bovone C, Sparano MC, Balestrazzi A, Caporossi A (2008) Corneal healing after riboflavin ultraviolet-A collagen cross-linking determined by confocal laser scanning microscopy in vivo: early and late modifications. Am J Ophthalmol 146:527–533. https://doi.org/10.1016/j.ajo.2008.05.042CrossRefPubMed

27.

Korkmaz MF, Parlakpinar H, Erdem MN, Ceylan MF, Ediz L, Samdanci E, Kekilli E (2020) The therapeutic efficacy of dexpanthenol on sciatic nerve injury in a rat model. Br J Neurosurg 34:397–401. https://doi.org/10.1080/02688697.2020.1749984CrossRefPubMed

28.

Cagini C, Messina M, Torroni G, Riccitelli F, Mariniello M, Dua HS (2020) Efficacy of topical microemulsion of fatty acids of the ω-3 series on the sub-epithelial corneal nerves regeneration after epithelium-off corneal collagen cross-linking for keratoconus. Int Ophthalmol 40:205–212. https://doi.org/10.1007/s10792-019-01170-0CrossRefPubMed

29.

Li-Mei W, Jie T, Shan-He W, Dong-Mei M, Peng-Jiu Y (2016) Anti-inflammatory and anti-oxidative effects of dexpanthenol on lipopolysaccharide induced acute lung injury in mice. Inflammation 39:1757–1763. https://doi.org/10.1007/s10753-016-0410-7CrossRefPubMed

30.

Çerman E, Özcan DÖ, Toker E (2017) Sterile corneal infiltrates after corneal collagen cross-linking: evaluation of risk factors. Acta Ophthalmol 95:199–204. https://doi.org/10.1111/aos.13218CrossRefPubMed

Titel: Dexpanthenol/sodium hyaluronate eye drops for corneal epithelial healing following corneal cross-linking in patients with keratoconus
verfasst von: Huri Sabur
Mutlu Acar
Publikationsdatum: 12.06.2023
Verlag: Springer Netherlands
Erschienen in: International Ophthalmology / Ausgabe 10/2023
Print ISSN: 0165-5701
Elektronische ISSN: 1573-2630
DOI: https://doi.org/10.1007/s10792-023-02751-w

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Dexpanthenol/sodium hyaluronate eye drops for corneal epithelial healing following corneal cross-linking in patients with keratoconus

Abstract

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Conclusion

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