Skip to main content
Erschienen in: Der Unfallchirurg 5/2016

09.05.2016 | Wundinfektion | Leitthema

Akute Maßnahmen beim „limb salvage“-Prozedere Teil 2

Debridement, Lavagetechniken und antiinfektiöse Strategien

verfasst von: Prof. Dr. C. Willy, M. Stichling, M. Müller, R. Gatzer, A. Kramer, D. A. Back, D. Vogt

Erschienen in: Die Unfallchirurgie | Ausgabe 5/2016

Einloggen, um Zugang zu erhalten

Zusammenfassung

Die Qualität der Primärversorgung von Gustilo-Anderson(GA)-IIIB- und -IIIC-Extremitätenverletzungen ist entscheidend für den Erfolg des „limb salvage“-Vorgehens. Vor dem Hintergrund eigener Erfahrungen und der aktuellen Literatur stellt dieser Beitrag die teilweise einheitlich, jedoch auch sehr kontrovers diskutierten Aspekte des initialen Debridements, der modernen Lavage- und Wundverschlusstechniken sowie aktuelle Aspekte der Antibiotika- und Antiseptikagabe zusammen. Herauszustellen ist: Bei schweren Extremitätenverletzungen mit ausgeprägter Kontamination (GA-IIIA, -IIIB und -IIIC) muss nach wie vor mit einer Infektionsrate von bis zu 60 % gerechnet werden. Das initiale Debridement sollte zum frühestmöglichen Zeitpunkt erfolgen, an dem ein erfahrener Traumachirurg verfügbar ist. Sicher avitales Gewebe wird entfernt; traumatisiertes, aber möglicherweise überlebendes Gewebe muss bei einem „second look“ nach 36–48 Stunden reevaluiert werden. Die Biofilmentwicklung setzt bei ausreichendem Kontaminationsausmaß bereits nach etwa 6 Stunden ein. Die perioperative Antibiotikaprophylaxe muss frühzeitig begonnen und sollte für 24 Stunden (GA-I und -II) bis zu 5 Tagen (GA-III) fortgesetzt werden. Bei bakterieller Kontamination sind Wundspüllösungen mit Zusätzen wie Polyhexanid, Octenidin oder superoxidiertem Wasser sinnvoll. Die Spülung der Wunde sollte nur mit leichtem manuellem Druck (keine Jet-Lavage) in einer Menge von 3–9 Litern erfolgen. Der definitive primäre Wundverschluss ist bei sicherer Dekontamination und Vitalität des Wundgrunds möglichst initial anzustreben (GA-I und -II). Bei höchstgradigen Verletzungen kann die temporäre Vakuumversiegelungstechnik die Zeit bis zum frühestmöglich anzustrebenden definitiven plastischen Wundverschluss überbrücken.
Anhänge
Nur mit Berechtigung zugänglich
Literatur
1.
Zurück zum Zitat Sathiyakumar V, Thakore RV, Stinner DJ, Obremskey WT, Ficke JR, Sethi MK (2015) Gunshot-induced fractures of the extremities: a review of antibiotic and debridement practices. Curr Rev Musculoskelet Med 8:276–289CrossRefPubMedPubMedCentral Sathiyakumar V, Thakore RV, Stinner DJ, Obremskey WT, Ficke JR, Sethi MK (2015) Gunshot-induced fractures of the extremities: a review of antibiotic and debridement practices. Curr Rev Musculoskelet Med 8:276–289CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Merens A, Rapp C, Delaune D, Danis J, Berger F, Michel R (2014) Prevention of combat-related infections: antimicrobial therapy in battlefield and barrier measures in French military medical treatment facilities. Travel Med Infect Dis 12:318–329CrossRefPubMed Merens A, Rapp C, Delaune D, Danis J, Berger F, Michel R (2014) Prevention of combat-related infections: antimicrobial therapy in battlefield and barrier measures in French military medical treatment facilities. Travel Med Infect Dis 12:318–329CrossRefPubMed
3.
Zurück zum Zitat Merritt K (1988) Factors increasing the risk of infection in patients with open fractures. J Trauma 28:823–827CrossRefPubMed Merritt K (1988) Factors increasing the risk of infection in patients with open fractures. J Trauma 28:823–827CrossRefPubMed
4.
Zurück zum Zitat Srour M, Inaba K, Okoye O et al (2015) Prospective evaluation of treatment of open fractures: effect of time to irrigation and debridement. JAMA Surg 150:332–336CrossRefPubMed Srour M, Inaba K, Okoye O et al (2015) Prospective evaluation of treatment of open fractures: effect of time to irrigation and debridement. JAMA Surg 150:332–336CrossRefPubMed
5.
Zurück zum Zitat Hull, Johnson SC, Stephen DJ, Kreder HJ, Jenkinson RJ (2014) Delayed debridement of severe open fractures is associated with a higher rate of deep infection. Bone Jt J 96:379–384CrossRef Hull, Johnson SC, Stephen DJ, Kreder HJ, Jenkinson RJ (2014) Delayed debridement of severe open fractures is associated with a higher rate of deep infection. Bone Jt J 96:379–384CrossRef
6.
Zurück zum Zitat Sears ED, Davis MM, Chung KC (2012) Relationship between timing of emergency procedures and limb amputation in patients with open tibia fracture in the United States, 2003 to 2009. Plast Reconstr Surg 130:369–378CrossRefPubMedPubMedCentral Sears ED, Davis MM, Chung KC (2012) Relationship between timing of emergency procedures and limb amputation in patients with open tibia fracture in the United States, 2003 to 2009. Plast Reconstr Surg 130:369–378CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Kollig E, Hentsch S, Willms A, Bieler D, Franke A (2014) Gunshot wounds: should projectiles and fragments always be removed? Chirurg 85:607–615CrossRefPubMed Kollig E, Hentsch S, Willms A, Bieler D, Franke A (2014) Gunshot wounds: should projectiles and fragments always be removed? Chirurg 85:607–615CrossRefPubMed
8.
Zurück zum Zitat Watters J, Anglen JO, Mullis BH (2011) The role of debridement in low-velocity civilian gunshot injuries resulting in pelvis fractures: a retrospective review of acute infection and inpatient mortality. J Orthop Trauma 25:150–155CrossRefPubMed Watters J, Anglen JO, Mullis BH (2011) The role of debridement in low-velocity civilian gunshot injuries resulting in pelvis fractures: a retrospective review of acute infection and inpatient mortality. J Orthop Trauma 25:150–155CrossRefPubMed
9.
Zurück zum Zitat Ricci WM, Collinge C, Streubel PN, McAndrew CM, Gardner MJ (2013) A comparison of more and less aggressive bone debridement protocols for the treatment of open supracondylar femur fractures. J Orthop Trauma 27:722–725CrossRefPubMedPubMedCentral Ricci WM, Collinge C, Streubel PN, McAndrew CM, Gardner MJ (2013) A comparison of more and less aggressive bone debridement protocols for the treatment of open supracondylar femur fractures. J Orthop Trauma 27:722–725CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Sassoon A, Riehl J, Rich A et al (2015) Muscle viability revisited: Are we removing normal muscle? A critical evaluation of dogmatic debridement. J Orthop Trauma 30:17CrossRef Sassoon A, Riehl J, Rich A et al (2015) Muscle viability revisited: Are we removing normal muscle? A critical evaluation of dogmatic debridement. J Orthop Trauma 30:17CrossRef
11.
Zurück zum Zitat Craig J, Fuchs T, Jenks M et al (2014) Systematic review and meta-analysis of the additional benefit of local prophylactic antibiotic therapy for infection rates in open tibia fractures treated with intramedullary nailing. Int Orthop 38:1025–1030CrossRefPubMedPubMedCentral Craig J, Fuchs T, Jenks M et al (2014) Systematic review and meta-analysis of the additional benefit of local prophylactic antibiotic therapy for infection rates in open tibia fractures treated with intramedullary nailing. Int Orthop 38:1025–1030CrossRefPubMedPubMedCentral
12.
Zurück zum Zitat Grote S, Polzer H, Prall WC et al (2012) Prevention of infection in the current treatment of open fractures: an evidence-based systematic analysis. Orthopade 41:32–42CrossRefPubMed Grote S, Polzer H, Prall WC et al (2012) Prevention of infection in the current treatment of open fractures: an evidence-based systematic analysis. Orthopade 41:32–42CrossRefPubMed
13.
Zurück zum Zitat Conway JD, Hlad LM, Bark SE (2015) Antibiotic cement-coated plates for management of infected fractures. Am J Orthop 44:E49–E53PubMed Conway JD, Hlad LM, Bark SE (2015) Antibiotic cement-coated plates for management of infected fractures. Am J Orthop 44:E49–E53PubMed
14.
Zurück zum Zitat Metsemakers WJ, Reul M, Nijs S (2015) The use of gentamicin-coated nails in complex open tibia fracture and revision cases: A retrospective analysis of a single centre case series and review of the literature. Injury 46(12):2433CrossRefPubMed Metsemakers WJ, Reul M, Nijs S (2015) The use of gentamicin-coated nails in complex open tibia fracture and revision cases: A retrospective analysis of a single centre case series and review of the literature. Injury 46(12):2433CrossRefPubMed
15.
Zurück zum Zitat FLOW investigators (2015) A trial of wound irrigation in the initial management of open fracture wounds. N Engl J Med 373:2629CrossRef FLOW investigators (2015) A trial of wound irrigation in the initial management of open fracture wounds. N Engl J Med 373:2629CrossRef
16.
Zurück zum Zitat Petrisor B, Jeray K, Schemitsch E et al (2008) Fluid lavage in patients with open fracture wounds (FLOW): an international survey of 984 surgeons. BMC Musculoskelet Disord 9:7CrossRefPubMedPubMedCentral Petrisor B, Jeray K, Schemitsch E et al (2008) Fluid lavage in patients with open fracture wounds (FLOW): an international survey of 984 surgeons. BMC Musculoskelet Disord 9:7CrossRefPubMedPubMedCentral
17.
Zurück zum Zitat Allen D, LaBarbera LA, Bondre IL et al (2014) Comparison of tissue damage, cleansing and cross-contamination potential during wound cleansing via two methods: lavage and negative pressure wound therapy with instillation. Int Wound J 11:198–209CrossRefPubMed Allen D, LaBarbera LA, Bondre IL et al (2014) Comparison of tissue damage, cleansing and cross-contamination potential during wound cleansing via two methods: lavage and negative pressure wound therapy with instillation. Int Wound J 11:198–209CrossRefPubMed
18.
Zurück zum Zitat Silva SR, Bosch P (2009) Intramuscular air as a complication of pulse-lavage irrigation. A case report. J Bone Jt Surg Am Vol 91:2937–2940CrossRef Silva SR, Bosch P (2009) Intramuscular air as a complication of pulse-lavage irrigation. A case report. J Bone Jt Surg Am Vol 91:2937–2940CrossRef
19.
Zurück zum Zitat Svoboda SJ, Bice TG, Gooden HA, Brooks DE, Thomas DB, Wenke JC (2006) Comparison of bulb syringe and pulsed lavage irrigation with use of a bioluminescent musculoskeletal wound model. J Bone Jt Surg Am 88: 2167:74 Svoboda SJ, Bice TG, Gooden HA, Brooks DE, Thomas DB, Wenke JC (2006) Comparison of bulb syringe and pulsed lavage irrigation with use of a bioluminescent musculoskeletal wound model. J Bone Jt Surg Am 88: 2167:74
20.
Zurück zum Zitat Owens BD, White DW, Wenke JC (2009) Comparison of irrigation solutions and devices in a contaminated musculoskeletal wound survival model. J Bone Jt Surg Am 91:92–98CrossRef Owens BD, White DW, Wenke JC (2009) Comparison of irrigation solutions and devices in a contaminated musculoskeletal wound survival model. J Bone Jt Surg Am 91:92–98CrossRef
21.
Zurück zum Zitat Urish KL, DeMuth PW, Craft DW, Haider H, Davis CM 3rd (2014) Pulse lavage is inadequate at removal of biofilm from the surface of total knee arthroplasty materials. J Arthroplasty 29:1128–1132CrossRefPubMed Urish KL, DeMuth PW, Craft DW, Haider H, Davis CM 3rd (2014) Pulse lavage is inadequate at removal of biofilm from the surface of total knee arthroplasty materials. J Arthroplasty 29:1128–1132CrossRefPubMed
22.
Zurück zum Zitat Wirtz D, Sellei RM, Portheine F, Prescher A, Weber M (2001) Effect of femoral intramedullary irrigation on periprosthetic cement distribution: jet lavage versus syringe lavage. Z Orthop Ihre Grenzgeb 139:410–414CrossRefPubMed Wirtz D, Sellei RM, Portheine F, Prescher A, Weber M (2001) Effect of femoral intramedullary irrigation on periprosthetic cement distribution: jet lavage versus syringe lavage. Z Orthop Ihre Grenzgeb 139:410–414CrossRefPubMed
23.
Zurück zum Zitat Breusch SJ, Schneider U, Reitzel T, Kreutzer J, Ewerbeck V, Lukoschek M (2001) Significance of jet lavage for in vitro and in vivo cement penetration. Z Orthop Ihre Grenzgeb 139:52–63CrossRefPubMed Breusch SJ, Schneider U, Reitzel T, Kreutzer J, Ewerbeck V, Lukoschek M (2001) Significance of jet lavage for in vitro and in vivo cement penetration. Z Orthop Ihre Grenzgeb 139:52–63CrossRefPubMed
24.
Zurück zum Zitat Keeman JN (2004) Treatment of open fractures before Lister and the management of the fatal leg fracture of Admiral Michiel Adriaensz de Ruyter, 1676. Ned Tijdschr Geneeskd 148:2607–2615PubMed Keeman JN (2004) Treatment of open fractures before Lister and the management of the fatal leg fracture of Admiral Michiel Adriaensz de Ruyter, 1676. Ned Tijdschr Geneeskd 148:2607–2615PubMed
25.
Zurück zum Zitat Penn-Barwell JG, Murray CK, Wenke JC (2012) Early antibiotics and debridement independently reduce infection in an open fracture model. J Bone Jt Surg Br Vol 94:107–112CrossRef Penn-Barwell JG, Murray CK, Wenke JC (2012) Early antibiotics and debridement independently reduce infection in an open fracture model. J Bone Jt Surg Br Vol 94:107–112CrossRef
26.
Zurück zum Zitat Wallum TE, Yun HC, Rini EA et al (2015) Pathogens present in acute mangled extremities from Afghanistan and subsequent pathogen recovery. Mil Med 180:97–103CrossRefPubMed Wallum TE, Yun HC, Rini EA et al (2015) Pathogens present in acute mangled extremities from Afghanistan and subsequent pathogen recovery. Mil Med 180:97–103CrossRefPubMed
27.
Zurück zum Zitat Sirijatuphat R, Siritongtaworn P, Sripojtham V, Boonyasiri A, Thamlikitkul V (2014) Bacterial contamination of fresh traumatic wounds at Trauma Center, Siriraj Hospital, Bangkok, Thailand. J Med Assoc Thai 97(Suppl 3):S20–S25PubMed Sirijatuphat R, Siritongtaworn P, Sripojtham V, Boonyasiri A, Thamlikitkul V (2014) Bacterial contamination of fresh traumatic wounds at Trauma Center, Siriraj Hospital, Bangkok, Thailand. J Med Assoc Thai 97(Suppl 3):S20–S25PubMed
28.
Zurück zum Zitat Johnson EN, Burns TC, Hayda RA, Hospenthal DR, Murray CK (2007) Infectious complications of open type III tibial fractures among combat casualties. Clin Infect Dis 45: 409:15 Johnson EN, Burns TC, Hayda RA, Hospenthal DR, Murray CK (2007) Infectious complications of open type III tibial fractures among combat casualties. Clin Infect Dis 45: 409:15
29.
Zurück zum Zitat Ryan SP, Pugliano V (2014) Controversies in initial management of open fractures. Scand J Surg 103:132–137CrossRefPubMed Ryan SP, Pugliano V (2014) Controversies in initial management of open fractures. Scand J Surg 103:132–137CrossRefPubMed
30.
Zurück zum Zitat Control ECfDPa (2013) Systematic review and evidence-based guidance on perioperative antibiotic prophylaxis. ECDC technical report. ECDC, Stockholm Control ECfDPa (2013) Systematic review and evidence-based guidance on perioperative antibiotic prophylaxis. ECDC technical report. ECDC, Stockholm
31.
Zurück zum Zitat de With K (2013) S3-Leitlinie – Strategien zur Sicherung rationaler Antibiotika-Anwendung im Krankenhaus. AWMF-Registernummer 092/001 de With K (2013) S3-Leitlinie – Strategien zur Sicherung rationaler Antibiotika-Anwendung im Krankenhaus. AWMF-Registernummer 092/001
32.
Zurück zum Zitat Gosselin RA, Roberts I, Gillespie WJ (2004) Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. doi:10.1002/14651858.CD003764PubMed Gosselin RA, Roberts I, Gillespie WJ (2004) Antibiotics for preventing infection in open limb fractures. Cochrane Database Syst Rev. doi:10.1002/14651858.CD003764PubMed
33.
Zurück zum Zitat Hoff WS, Bonadies JA, Cachecho R, Dorlac WC (2011) East Practice Management Guidelines Work Group: update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 70:751–754CrossRefPubMed Hoff WS, Bonadies JA, Cachecho R, Dorlac WC (2011) East Practice Management Guidelines Work Group: update to practice management guidelines for prophylactic antibiotic use in open fractures. J Trauma 70:751–754CrossRefPubMed
34.
Zurück zum Zitat Patzakis MJ, Harvey JP Jr., Ivler D (1974) The role of antibiotics in the management of open fractures. J Bone Joint Surg Am 56:532–541PubMed Patzakis MJ, Harvey JP Jr., Ivler D (1974) The role of antibiotics in the management of open fractures. J Bone Joint Surg Am 56:532–541PubMed
35.
Zurück zum Zitat Abele-Horn M (2010) Antimikrobielle Therapie. Peter Wiehl, Marburg, S 315 Abele-Horn M (2010) Antimikrobielle Therapie. Peter Wiehl, Marburg, S 315
36.
Zurück zum Zitat Kleber C, Trampuz A (2014) Antibiotikaprophylaxe in der Orthopädie und Unfallchirurgie – was, wann und wie lange applizieren. OP J 30:8–10CrossRef Kleber C, Trampuz A (2014) Antibiotikaprophylaxe in der Orthopädie und Unfallchirurgie – was, wann und wie lange applizieren. OP J 30:8–10CrossRef
37.
Zurück zum Zitat Abele-Horn M (2010) Antimikrobielle Therapie. Peter Wiehl, Marburg, S 166 Abele-Horn M (2010) Antimikrobielle Therapie. Peter Wiehl, Marburg, S 166
38.
Zurück zum Zitat Steller D, Willy C (2013) Literature analysis on the topic „Antiseptics for the treatment of acute soft tissue and bone wounds“ following the guidelines of „Evidence-based medicine“. In: Willy C (Hrsg) Antiseptics in surgery – update 2013, scientific basis, indications for use, evidence based recommendations, vacuum instillation therapy. Lindqvist Book Publishing, Ulm (Donau), S 33–82 Steller D, Willy C (2013) Literature analysis on the topic „Antiseptics for the treatment of acute soft tissue and bone wounds“ following the guidelines of „Evidence-based medicine“. In: Willy C (Hrsg) Antiseptics in surgery – update 2013, scientific basis, indications for use, evidence based recommendations, vacuum instillation therapy. Lindqvist Book Publishing, Ulm (Donau), S 33–82
39.
Zurück zum Zitat Kramer A, Assadian O, Below H (2013) Wound antiseptics today – an overview. In: Willy C (Hrsg) Antiseptics in surgery – update 2013, scientific basis, indications for use, evidence based recommendations, vacuum instillation therapy. Lindqvist Book Publishing, Ulm (Donau), S 83–105 Kramer A, Assadian O, Below H (2013) Wound antiseptics today – an overview. In: Willy C (Hrsg) Antiseptics in surgery – update 2013, scientific basis, indications for use, evidence based recommendations, vacuum instillation therapy. Lindqvist Book Publishing, Ulm (Donau), S 83–105
40.
Zurück zum Zitat Muller G, Kramer A (2008) Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity. J Antimicrob Chemother 61:1281–1287CrossRefPubMed Muller G, Kramer A (2008) Biocompatibility index of antiseptic agents by parallel assessment of antimicrobial activity and cellular cytotoxicity. J Antimicrob Chemother 61:1281–1287CrossRefPubMed
41.
Zurück zum Zitat Wiegand C, Abel M, Ruth P, Hipler UC (2009) HaCaT keratinocytes in co-culture with Staphylococcus aureus can be protected from bacterial damage by polihexanide. Wound Repair Regen 17:730–738CrossRefPubMed Wiegand C, Abel M, Ruth P, Hipler UC (2009) HaCaT keratinocytes in co-culture with Staphylococcus aureus can be protected from bacterial damage by polihexanide. Wound Repair Regen 17:730–738CrossRefPubMed
42.
Zurück zum Zitat Crabtree TD, Pelletier SJ, Pruett TL (2001) Surgical antisepsis. In: Block SS (Hrsg) Disinfection, sterilization, and preservation. Lippincott Williams Wilkins, Philadelphia, S 919–934 Crabtree TD, Pelletier SJ, Pruett TL (2001) Surgical antisepsis. In: Block SS (Hrsg) Disinfection, sterilization, and preservation. Lippincott Williams Wilkins, Philadelphia, S 919–934
43.
Zurück zum Zitat Wenzel E, Stang F, Hasemann B, Kisch T et al (2012) Prospective, double-blinded, randomised controlled trial assessing the effect of an Octenidine-based hydrogel on bacterial colonisation and epithelialization of skin graft wounds in burn patients. Int J Burns Trauma 2:71–79 Wenzel E, Stang F, Hasemann B, Kisch T et al (2012) Prospective, double-blinded, randomised controlled trial assessing the effect of an Octenidine-based hydrogel on bacterial colonisation and epithelialization of skin graft wounds in burn patients. Int J Burns Trauma 2:71–79
44.
Zurück zum Zitat Takesue Y, Takahashi Y, Ichiki K et al (2011) Application of an electrolyzed strongly acidic aqueous solution before wound closure in colorectal surgery. Dis Colon Rectum 54:826–832CrossRefPubMed Takesue Y, Takahashi Y, Ichiki K et al (2011) Application of an electrolyzed strongly acidic aqueous solution before wound closure in colorectal surgery. Dis Colon Rectum 54:826–832CrossRefPubMed
45.
Zurück zum Zitat Mohd AR, Ghani MK, Awang RR, Su Min JO, Dimon MZ (2010) Dermacyn irrigation in reducing infection of a median sternotomy wound. Heart Surg Forum 13:E228–E232CrossRefPubMed Mohd AR, Ghani MK, Awang RR, Su Min JO, Dimon MZ (2010) Dermacyn irrigation in reducing infection of a median sternotomy wound. Heart Surg Forum 13:E228–E232CrossRefPubMed
46.
Zurück zum Zitat Kokavec M, Fristakova M (2008) Efficacy of antiseptics in the prevention of post-operative infections of the proximal femur, hip and pelvis regions in orthopedic pediatric patients. Analysis of the first results. Acta Chir Orthop Traumatol Cech 75:106–109PubMed Kokavec M, Fristakova M (2008) Efficacy of antiseptics in the prevention of post-operative infections of the proximal femur, hip and pelvis regions in orthopedic pediatric patients. Analysis of the first results. Acta Chir Orthop Traumatol Cech 75:106–109PubMed
47.
Zurück zum Zitat Kapur V, Marwaha AK (2011) Evaluation of effect and comparison of superoxidised solution (oxum) v/s povidone iodine (betadine). Indian J Surg 73:48–53CrossRefPubMedPubMedCentral Kapur V, Marwaha AK (2011) Evaluation of effect and comparison of superoxidised solution (oxum) v/s povidone iodine (betadine). Indian J Surg 73:48–53CrossRefPubMedPubMedCentral
48.
Zurück zum Zitat Hadi SF, Khaliq T, Bilal N et al (2007) Treating infected diabetic wounds with superoxidized water as anti-septic agent : a preliminary experience. J Coll Physicians Surg Pak 17:740–743PubMed Hadi SF, Khaliq T, Bilal N et al (2007) Treating infected diabetic wounds with superoxidized water as anti-septic agent : a preliminary experience. J Coll Physicians Surg Pak 17:740–743PubMed
49.
Zurück zum Zitat Fournel I, Tiv M, Soulias M, Hua C, Astruc K, Aho Glele LS (2010) Meta-analysis of intraoperative povidone-iodine application to prevent surgical-site infection. Br J Surg 97:1603–1613CrossRefPubMed Fournel I, Tiv M, Soulias M, Hua C, Astruc K, Aho Glele LS (2010) Meta-analysis of intraoperative povidone-iodine application to prevent surgical-site infection. Br J Surg 97:1603–1613CrossRefPubMed
50.
Zurück zum Zitat Becerro de Bengoa Vallejo R, Losa Iglesias ME, Cervera LA, Fernandez DS, Prieto JP (2011) Efficacy of intraoperative surgical irrigation with polihexanide and nitrofurazone in reducing bacterial load after nail removal surgery. J Am Acad Dermatol 64:328–335CrossRefPubMed Becerro de Bengoa Vallejo R, Losa Iglesias ME, Cervera LA, Fernandez DS, Prieto JP (2011) Efficacy of intraoperative surgical irrigation with polihexanide and nitrofurazone in reducing bacterial load after nail removal surgery. J Am Acad Dermatol 64:328–335CrossRefPubMed
51.
Zurück zum Zitat Abhyankar SV, Venkatesh V, Karnad S et al (2009) Efficacy and safety of oxum in treatment of chronic wounds. J Indian Med Assoc 107:904–906PubMed Abhyankar SV, Venkatesh V, Karnad S et al (2009) Efficacy and safety of oxum in treatment of chronic wounds. J Indian Med Assoc 107:904–906PubMed
52.
Zurück zum Zitat Back DA, Scheuermann-Poley C, Willy C (2013) Recommendations on negative pressure wound therapy with instillation and antimicrobial solutions – when, where and how to use: what does the evidence show? int Wound J 10(Suppl 1):32–42CrossRefPubMed Back DA, Scheuermann-Poley C, Willy C (2013) Recommendations on negative pressure wound therapy with instillation and antimicrobial solutions – when, where and how to use: what does the evidence show? int Wound J 10(Suppl 1):32–42CrossRefPubMed
53.
Zurück zum Zitat Rajasekaran S, Dheenadhayalan J, Babu JN, Sundararajan SR, Venkatramani H, Sabapathy SR (2009) Immediate primary skin closure in type-III A and B open fractures: results after a minimum of five years. J Bone Jt Surg Br Vol 91:217–224CrossRef Rajasekaran S, Dheenadhayalan J, Babu JN, Sundararajan SR, Venkatramani H, Sabapathy SR (2009) Immediate primary skin closure in type-III A and B open fractures: results after a minimum of five years. J Bone Jt Surg Br Vol 91:217–224CrossRef
55.
Zurück zum Zitat Moola FO, Carli A, Berry GK, Reindl R, Jacks D, Harvey EJ (2014) Attempting primary closure for all open fractures: the effectiveness of an institutional protocol. Can J Surg J Can De Chir 57:E82–E88CrossRef Moola FO, Carli A, Berry GK, Reindl R, Jacks D, Harvey EJ (2014) Attempting primary closure for all open fractures: the effectiveness of an institutional protocol. Can J Surg J Can De Chir 57:E82–E88CrossRef
56.
Zurück zum Zitat Crist BD, Rocca GJ Della, Stannard JP (2010) Compartment syndrome surgical management techniques associated with tibial plateau fractures. J Knee Surg 23:3–7CrossRefPubMed Crist BD, Rocca GJ Della, Stannard JP (2010) Compartment syndrome surgical management techniques associated with tibial plateau fractures. J Knee Surg 23:3–7CrossRefPubMed
57.
Zurück zum Zitat Liu DS, Sofiadellis F, Ashton M, MacGill K, Webb A (2012) Early soft tissue coverage and negative pressure wound therapy optimises patient outcomes in lower limb trauma. Injury 43:772–778CrossRefPubMed Liu DS, Sofiadellis F, Ashton M, MacGill K, Webb A (2012) Early soft tissue coverage and negative pressure wound therapy optimises patient outcomes in lower limb trauma. Injury 43:772–778CrossRefPubMed
58.
Zurück zum Zitat Steiert AE, Gohritz A, Schreiber TC, Krettek C, Vogt PM (2009) Delayed flap coverage of open extremity fractures after previous vacuum-assisted closure (VAC) therapy – worse or worth? J Plast Reconstr Aesthetic Surg 62:675–683CrossRef Steiert AE, Gohritz A, Schreiber TC, Krettek C, Vogt PM (2009) Delayed flap coverage of open extremity fractures after previous vacuum-assisted closure (VAC) therapy – worse or worth? J Plast Reconstr Aesthetic Surg 62:675–683CrossRef
59.
Zurück zum Zitat Hwang KT, Kim SW, Sung IH, Kim JT, Kim YH (2015) Is delayed reconstruction using the latissimus dorsi free flap a worthy option in the management of open IIIB tibial fractures? Microsurgery. doi:10.1002/micr.22428. [Epub ahead of print] Hwang KT, Kim SW, Sung IH, Kim JT, Kim YH (2015) Is delayed reconstruction using the latissimus dorsi free flap a worthy option in the management of open IIIB tibial fractures? Microsurgery. doi:10.1002/micr.22428. [Epub ahead of print]
60.
Zurück zum Zitat Brinkert D, Ali M, Naud M, Maire N, Trial C, Teot L (2013) Negative pressure wound therapy with saline instillation: 131 patient case series. int Wound J 10(Suppl 1):56–60CrossRefPubMed Brinkert D, Ali M, Naud M, Maire N, Trial C, Teot L (2013) Negative pressure wound therapy with saline instillation: 131 patient case series. int Wound J 10(Suppl 1):56–60CrossRefPubMed
61.
Zurück zum Zitat Borrero EMP, Begines BR, Rodriguez LS, Diaz CT (2013) Managing complications in severe traumatic injury with VAC therapy with instillation. Revista De Enfermeria 36:42–47 Borrero EMP, Begines BR, Rodriguez LS, Diaz CT (2013) Managing complications in severe traumatic injury with VAC therapy with instillation. Revista De Enfermeria 36:42–47
62.
Zurück zum Zitat Brem MH, Blanke M, Olk A et al (2008) The vacuum-assisted closure (V.A.C.) and instillation dressing: limb salvage after 3 degrees open fracture with massive bone and soft tissue defect and superinfection. Unfallchirurg 111:122–125CrossRefPubMed Brem MH, Blanke M, Olk A et al (2008) The vacuum-assisted closure (V.A.C.) and instillation dressing: limb salvage after 3 degrees open fracture with massive bone and soft tissue defect and superinfection. Unfallchirurg 111:122–125CrossRefPubMed
63.
Zurück zum Zitat Trampuz A, Widmer AF (2006) Infections associated with orthopedic implants. Curr Opin Infect Dis 19:349–356CrossRefPubMed Trampuz A, Widmer AF (2006) Infections associated with orthopedic implants. Curr Opin Infect Dis 19:349–356CrossRefPubMed
64.
Zurück zum Zitat Davis SC, Ricotti C, Cazzaniga A, Welsh E, Eaglstein WH, Mertz PM (2008) Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo. Wound Repair Regen 16:23–29CrossRefPubMed Davis SC, Ricotti C, Cazzaniga A, Welsh E, Eaglstein WH, Mertz PM (2008) Microscopic and physiologic evidence for biofilm-associated wound colonization in vivo. Wound Repair Regen 16:23–29CrossRefPubMed
65.
Zurück zum Zitat Harrison-Balestra C, Cazzaniga AL, Davis SC, Mertz PM (2003) A wound-isolated Pseudomonas aeruginosa grows a biofilm in vitro within 10 hours and is visualized by light microscopy. Dermatol Surg 29:631–635PubMed Harrison-Balestra C, Cazzaniga AL, Davis SC, Mertz PM (2003) A wound-isolated Pseudomonas aeruginosa grows a biofilm in vitro within 10 hours and is visualized by light microscopy. Dermatol Surg 29:631–635PubMed
67.
Zurück zum Zitat Wolcott RD, Rhoads DD, Bennett ME et al (2010) Chronic wounds and the medical biofilm paradigm. J Wound Care 19:45–46 (8–50, 2–3)CrossRefPubMed Wolcott RD, Rhoads DD, Bennett ME et al (2010) Chronic wounds and the medical biofilm paradigm. J Wound Care 19:45–46 (8–50, 2–3)CrossRefPubMed
68.
Zurück zum Zitat Pattnaik A, Sarkar R, Sharma A et al (2013) Pharmacological studies on Buchanania lanzan Spreng.– a focus on wound healing with particular reference to anti-biofilm properties. Asian Pac J Trop Biomed 3:967–974CrossRefPubMedPubMedCentral Pattnaik A, Sarkar R, Sharma A et al (2013) Pharmacological studies on Buchanania lanzan Spreng.– a focus on wound healing with particular reference to anti-biofilm properties. Asian Pac J Trop Biomed 3:967–974CrossRefPubMedPubMedCentral
69.
Zurück zum Zitat Boyce BM, Lindsey BA, Clovis NB et al (2012) Additive effects of exogenous IL-12 supplementation and antibiotic treatment in infection prophylaxis. J Orthop Res 30:196–202CrossRefPubMedPubMedCentral Boyce BM, Lindsey BA, Clovis NB et al (2012) Additive effects of exogenous IL-12 supplementation and antibiotic treatment in infection prophylaxis. J Orthop Res 30:196–202CrossRefPubMedPubMedCentral
70.
Zurück zum Zitat Singh K, Bauer JM, LaChaud GY, Bible JE, Mir HR (2015) Surgical site infection in high-energy peri-articular tibia fractures with intra-wound vancomycin powder: a retrospective pilot study. J Orthop Traumatol 16:287–291CrossRefPubMedPubMedCentral Singh K, Bauer JM, LaChaud GY, Bible JE, Mir HR (2015) Surgical site infection in high-energy peri-articular tibia fractures with intra-wound vancomycin powder: a retrospective pilot study. J Orthop Traumatol 16:287–291CrossRefPubMedPubMedCentral
72.
Zurück zum Zitat Weber D, Dulai SK, Bergman J, Buckley R, Beaupre LA (2014) Time to initial operative treatment following open fracture does not impact development of deep infection: a prospective cohort study of 736 subjects. J Orthop Trauma 28:613–619CrossRefPubMed Weber D, Dulai SK, Bergman J, Buckley R, Beaupre LA (2014) Time to initial operative treatment following open fracture does not impact development of deep infection: a prospective cohort study of 736 subjects. J Orthop Trauma 28:613–619CrossRefPubMed
73.
Zurück zum Zitat Liang Y, Fang Y, Tu CQ, Yao XY, Yang TF (2014) Analyzing risk factors for surgical site infection following Pilon fracture surgery. China J Orthop Traumatol 27:650–653 Liang Y, Fang Y, Tu CQ, Yao XY, Yang TF (2014) Analyzing risk factors for surgical site infection following Pilon fracture surgery. China J Orthop Traumatol 27:650–653
74.
Zurück zum Zitat Stall A, Paryavi E, Gupta R, Zadnik M, Hui E, O’Toole RV (2013) Perioperative supplemental oxygen to reduce surgical site infection after open fixation of high-risk fractures: a randomized controlled pilot trial. J Trauma Acute Care Surg 75:657–663CrossRefPubMed Stall A, Paryavi E, Gupta R, Zadnik M, Hui E, O’Toole RV (2013) Perioperative supplemental oxygen to reduce surgical site infection after open fixation of high-risk fractures: a randomized controlled pilot trial. J Trauma Acute Care Surg 75:657–663CrossRefPubMed
75.
Zurück zum Zitat Singh J, Rambani R, Hashim Z, Raman R, Sharma HK (2012) The relationship between time to surgical debridement and incidence of infection in grade III open fractures. strategies Trauma Limb Reconstr 7:33–37CrossRefPubMedPubMedCentral Singh J, Rambani R, Hashim Z, Raman R, Sharma HK (2012) The relationship between time to surgical debridement and incidence of infection in grade III open fractures. strategies Trauma Limb Reconstr 7:33–37CrossRefPubMedPubMedCentral
76.
Zurück zum Zitat Chua W, Murphy D, Siow W, Kagda F, Thambiah J (2012) Epidemiological analysis of outcomes in 323 open tibial diaphyseal fractures: a nine-year experience. Singapore Med J 53:385–389PubMed Chua W, Murphy D, Siow W, Kagda F, Thambiah J (2012) Epidemiological analysis of outcomes in 323 open tibial diaphyseal fractures: a nine-year experience. Singapore Med J 53:385–389PubMed
77.
Zurück zum Zitat Burns TC, Stinner DJ, Mack AW et al (2012) Microbiology and injury characteristics in severe open tibia fractures from combat. J Trauma Acute Care Surg 72:1062–1067CrossRefPubMed Burns TC, Stinner DJ, Mack AW et al (2012) Microbiology and injury characteristics in severe open tibia fractures from combat. J Trauma Acute Care Surg 72:1062–1067CrossRefPubMed
78.
Zurück zum Zitat Lenarz CJ, Watson JT, Moed BR, Israel H, Mullen JD, Macdonald JB (2010) Timing of wound closure in open fractures based on cultures obtained after debridement. the J Bone Jt Surg Am Vol 92:1921–1926CrossRef Lenarz CJ, Watson JT, Moed BR, Israel H, Mullen JD, Macdonald JB (2010) Timing of wound closure in open fractures based on cultures obtained after debridement. the J Bone Jt Surg Am Vol 92:1921–1926CrossRef
79.
Zurück zum Zitat Parekh AA, Smith WR, Silva S et al (2008) Treatment of distal femur and proximal tibia fractures with external fixation followed by planned conversion to internal fixation. J Trauma 64:736–739CrossRefPubMed Parekh AA, Smith WR, Silva S et al (2008) Treatment of distal femur and proximal tibia fractures with external fixation followed by planned conversion to internal fixation. J Trauma 64:736–739CrossRefPubMed
80.
Zurück zum Zitat Bhattacharyya T, Mehta P, Smith M, Pomahac B (2008) Routine use of wound vacuum-assisted closure does not allow coverage delay for open tibia fractures. Plast Reconstr Surg 121:1263–1266CrossRefPubMed Bhattacharyya T, Mehta P, Smith M, Pomahac B (2008) Routine use of wound vacuum-assisted closure does not allow coverage delay for open tibia fractures. Plast Reconstr Surg 121:1263–1266CrossRefPubMed
Metadaten
Titel
Akute Maßnahmen beim „limb salvage“-Prozedere Teil 2
Debridement, Lavagetechniken und antiinfektiöse Strategien
verfasst von
Prof. Dr. C. Willy
M. Stichling
M. Müller
R. Gatzer
A. Kramer
D. A. Back
D. Vogt
Publikationsdatum
09.05.2016
Verlag
Springer Berlin Heidelberg
Erschienen in
Die Unfallchirurgie / Ausgabe 5/2016
Print ISSN: 2731-7021
Elektronische ISSN: 2731-703X
DOI
https://doi.org/10.1007/s00113-016-0178-0

Weitere Artikel der Ausgabe 5/2016

Der Unfallchirurg 5/2016 Zur Ausgabe

Zertifizierte Fortbildung – OP-Technik

Operative Versorgung der Symphysensprengung

Arthropedia

Grundlagenwissen der Arthroskopie und Gelenkchirurgie. Erweitert durch Fallbeispiele, Videos und Abbildungen. 
» Jetzt entdecken

Häusliche Gewalt in der orthopädischen Notaufnahme oft nicht erkannt

28.05.2024 Traumatologische Notfälle Nachrichten

In der Notaufnahme wird die Chance, Opfer von häuslicher Gewalt zu identifizieren, von Orthopäden und Orthopädinnen offenbar zu wenig genutzt. Darauf deuten die Ergebnisse einer Fragebogenstudie an der Sahlgrenska-Universität in Schweden hin.

Fehlerkultur in der Medizin – Offenheit zählt!

Darüber reden und aus Fehlern lernen, sollte das Motto in der Medizin lauten. Und zwar nicht nur im Sinne der Patientensicherheit. Eine negative Fehlerkultur kann auch die Behandelnden ernsthaft krank machen, warnt Prof. Dr. Reinhard Strametz. Ein Plädoyer und ein Leitfaden für den offenen Umgang mit kritischen Ereignissen in Medizin und Pflege.

Mehr Frauen im OP – weniger postoperative Komplikationen

21.05.2024 Allgemeine Chirurgie Nachrichten

Ein Frauenanteil von mindestens einem Drittel im ärztlichen Op.-Team war in einer großen retrospektiven Studie aus Kanada mit einer signifikanten Reduktion der postoperativen Morbidität assoziiert.

„Übersichtlicher Wegweiser“: Lauterbachs umstrittener Klinik-Atlas ist online

17.05.2024 Klinik aktuell Nachrichten

Sie sei „ethisch geboten“, meint Gesundheitsminister Karl Lauterbach: mehr Transparenz über die Qualität von Klinikbehandlungen. Um sie abzubilden, lässt er gegen den Widerstand vieler Länder einen virtuellen Klinik-Atlas freischalten.

Update Orthopädie und Unfallchirurgie

Bestellen Sie unseren Fach-Newsletter und bleiben Sie gut informiert.