Pediatric Nephrology OnlineFirst articles

Open Access 27.05.2024 | Clinical Insights

Acute kidney injury in lamotrigine-induced DRESS syndrome

We present a case of lamotrigine-triggered DRESS (drug reaction with eosinophilia and systemic symptoms) syndrome with acute kidney injury stage 3. A 17-year-old girl with known epilepsy treated with lamotrigine presented with acute kidney injury …

verfasst von:: Klara Kristin Brüning, Elena Pelivan, Marie-Christine Heinrich, Philip Bufler, Angela Kaindl, Julia Thumfart

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27.05.2024 | Review

Role of miRNAs in macrophage-mediated kidney injury

Macrophages, crucial components of the human immune system, can be polarized into M1/M2 phenotypes, each with distinct functions and roles. Macrophage polarization has been reported to be significantly involved in the inflammation and fibrosis …

verfasst von:: Junxin Li, Xida Yan, Zhigui Wu, Jing Shen, Yalin Li, Yueshui Zhao, Fukuan Du, Mingxing Li, Xu Wu, Yu Chen, Zhangang Xiao, Shurong Wang

23.05.2024 | Original Article

Clinicopathological characteristics of pediatric ANCA-associated glomerulonephritis

Anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) is a rare subgroup of primary systemic vasculitides, characterized by the presence of inflammation affecting the walls of small blood vessels (i.e., capillaries, venules, and …

verfasst von:: Olga Charnaya, Jacqueline Kruglyakova, Binil Jacob, Lois J. Arend

Open Access 23.05.2024 | Clinical Insights

An unusual case of nephrotic syndrome

A 15-year-old female presented with a 2-week history of pedal oedema. She reported no antecedent illness, fever, arthropathy or rash. In early childhood, the patient had attended a general paediatrician for recurrent urinary tract infections. The …

verfasst von:: Dermot Michael Wildes, Aisling Fitzsimons, Brendan Doyle, Andrew Green, Clodagh Sweeney, Atif Awan

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Open Access 22.05.2024 | Clinical Insights

Managing recurrent parvovirus B19-associated anemia after a pediatric kidney transplant

A 13-year-old girl who had a kidney transplant four weeks prior presented with a 10-day history of fatigue, paleness, and headache. On physical examination, tachycardia and paleness were noted. Laboratory testing was notable for severe anemia and …

verfasst von:: Mehmet Sabanci, Mehmet Taşdemir, Burcu Öksüz, Yasemin Altuner Torun, Murat Sütçü, Ozan Özkaya

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Open Access 21.05.2024 | Original Article

Association of problems, coping styles, and preferred online activity with depression, anxiety, and other psychological disorders in Turkish adolescents diagnosed with chronic kidney disease

Chronic kidney disease (CKD) refers to a progressive and irreversible loss of glomerular filtration due to structural kidney damage [ 1 ]. Beyond the challenges of the disease process and complications, psychiatric and psychosocial outcomes also …

verfasst von:: Ibrahim Kandemir, Kemal Gudek, Aylin Yetim Sahin, Melike Tugrul Aksakal, Elif Kucuk, Zeynep Nagehan Yuruk Yildirim, Alev Yilmaz, Ahmet Nayir, Firdevs Bas

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21.05.2024 | Editorial Commentary

Kidney point-of-care ultrasonography in the PICU: it is about time!

Reliable biomarkers that may serve as early prognostic measures in patients at risk of developing AKI continue to be sought after, while the care of patients with AKI continues to rely on lagging measures such as serum creatinine, cystatin C, and …

verfasst von:: Aline Vasconcelos De Carvalho, Fabiane Mendes De Souza, Scott Thomas McEwen, Tiago Henrique De Souza

21.05.2024 | Research Letter

Treatment of paediatric renal tubular acidosis with a prolonged-release alkali supplementation

verfasst von:: Hai Liang Tan, Matko Marlais, Faidra Veligratli, Sarit Shah, Wesley Hayes, Detlef Bockenhauer

Open Access 20.05.2024 | Original Article

Genetic determinants of renal scarring in children with febrile UTI

Urinary tract infection (UTI) is a common bacterial infection in childhood, affecting approximately 2% of all infants [ 1 ]. Urosepsis and acute pyelonephritis (APN) are the most severe forms of UTI, leading to systemic infections with kidney …

verfasst von:: Therese Rosenblad, Magnus Lindén, Ines Ambite, Per Brandström, Sverker Hansson, Gabriela Godaly

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18.05.2024 | Original Article

Clinician response after receipt of abnormal pediatric ambulatory blood pressure monitoring – characteristics associated with inertia and action

Cardiovascular (CV) disease (CVD) is the main cause of death in the United States [ 1 ]. CVD risk factors such as hypertension, obesity, and dyslipidemia are increasingly prevalent in childhood [ 2 , 3 ] and in adulthood can lead to significant CV …

verfasst von:: Evelien van Gelderen, Kevin J. Psoter, Rafi Faria, Cozumel Pruette, Tammy M. Brady

16.05.2024 | Review

Diagnosis and management of primary hyperoxalurias: best practices

The primary hyperoxalurias (PH) are rare autosomal recessive disorders of glyoxylate metabolism resulting in hepatic overproduction of oxalate. Excess oxalate is excreted by the kidneys and can precipitate as insoluble calcium oxalate crystals …

verfasst von:: Mini Michael, Elizabeth Harvey, Dawn S. Milliner, Yaacov Frishberg, David J. Sas, Juan Calle, Lawrence Copelovitch, Kristina L. Penniston, Jeffrey Saland, Michael J. G. Somers, Michelle A. Baum

16.05.2024 | Clinical Insights

Antenatal presentation and early postnatal treatment of infantile hypercalcemia type 2

Infantile hypercalcemia (IH) is a rare genetic disorder characterized by hypercalcemia, hypercalciuria, low parathyroid hormone, and nephrocalcinosis during the first months of life. Biallelic variants in the genes CYP24A1 and SCL34A1 cause IH1 …

verfasst von:: Marcelien Verjans, An Hindryckx, Karen Rosier, Koen Devriendt, Djalila Mekahli, Detlef Bockenhauer

14.05.2024 | Original Article

Activin A: a marker of mineral bone disorder in children with chronic kidney disease?

Mineral bone disease (MBD) is an important cause of cardiovascular morbidity and mortality in children with chronic kidney disease (CKD). Abnormalities of calcium, phosphorus, parathyroid hormone (PTH) and vitamin D along with bone mineralisation …

verfasst von:: Raagul Shankar, Abhijeet Saha, Rachita Singh Dhull, Rukshana Shroff, Anita Nangia, Sunita Sharma

13.05.2024 | Original Article

Renal resistive index by point of care ultrasound to predict sepsis associated acute kidney injury in critically ill children

Acute kidney injury (AKI) is one of the most common organ dysfunctions in children admitted to the pediatric intensive care unit (PICU). The reported incidence of AKI was 26.9% and severe AKI was 11.6% in critically ill children and young adults [ …

verfasst von:: Muthuvel Rajangam, Karthi Nallasamy, Anmol Bhatia, Vinod Kumar, Prabhjot Kaur, Suresh Kumar Angurana

Open Access 11.05.2024 | Original Article

Dialysis for paediatric acute kidney injury in Cape Town, South Africa

Major advances in the management of acute kidney injury (AKI) globally, including improvements in kidney replacement therapies, have enabled even infants and small children to be dialysed [ 1 ]. However, most low and lower middle-income countries …

verfasst von:: Mignon I. McCulloch, Valerie A. Luyckx, Brenda Morrow, Peter Nourse, Ashton Coetzee, Deveshni Reddy, Christel Du Buisson, Jonathan Buckley, Ilana Webber, Alp Numanoglu, Gina Sinclair, Candice Nelson, Shamiel Salie, Kirsten Reichmuth, Andrew C. Argent

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Open Access 08.05.2024 | Original Article

Dyslipidemia in children with chronic kidney disease—findings from the Cardiovascular Comorbidity in Children with Chronic Kidney Disease (4C) study

Dyslipidemia is a common metabolic complication of chronic kidney disease (CKD). Prior to dialysis or transplantation, CKD is typically associated with increased levels of triglycerides (TGs) and a decrease in high-density lipoprotein cholesterol …

verfasst von:: Francesca Mencarelli, Karolis Azukaitis, Marietta Kirchner, Aysun Bayazit, Ali Duzova, Nur Canpolat, Ipek Kaplan Bulut, Lukasz Obrycki, Bruno Ranchin, Rukshana Shroff, Salim Caliskan, Cengiz Candan, Alev Yilmaz, Zeynep Birsin Özcakar, Harika Halpay, Aysel Kiyak, Hakan Erdogan, Jutta Gellermann, Ayse Balat, Anette Melk, Franz Schaefer, Uwe Querfeld

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Open Access 08.05.2024 | Correction

Correction: Use of ClearGuard HD caps in pediatric hemodialysis patients

verfasst von:: Amy Nau, Troy Richardson, Diana Cardwell, Jennifer Ehrlich, Jyothsna Gattineni, Melisha Hanna, Mahima Keswani, Emily Neibauer, Kelly Nitz, Raymond Quigley, Michelle Rheault, Rebekah Sims, Mayna Woo, Bradley A. Warady

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07.05.2024 | Original Article

Diuretic response after neonatal cardiac surgery: a report from the NEPHRON collaborative

Cardiac surgery–associated acute kidney injury (CS-AKI) is associated with morbidity, resource utilization, and mortality [ 1 – 4 ]. Existing definitions rely on serum creatinine (SC) changes, oligo-anuria, and kidney replacement therapy (KRT) to …

verfasst von:: Joshua J. Blinder, Jeffrey Alten, David Bailly, Jason Buckley, Shanelle Clarke, J. Wesley Diddle, Xiomara Garcia, Katja M. Gist, Joshua Koch, David M. Kwiatkowski, A. K. M. Fazlur Rahman, Garrett Reichle, Kevin Valentine, Kristal M. Hock, Santiago Borasino, NEPHRON Collaborators

02.05.2024 | Original Article

Sodium removal per ultrafiltration volume in automated peritoneal dialysis in pediatric patients

Patients on peritoneal dialysis (PD) have a tendency to fluid overload [ 1 ], which induces hypertension, a risk factor of cardiovascular disease (CVD). CVD is a common cause of death in patients on PD, including children [ 2 ]. Therefore, the …

verfasst von:: Takashi Tokunaga, Riku Hamada, Tomohiro Inoguchi, Chikako Terano, Naoaki Mikami, Ryoko Harada, Yuko Hamasaki, Kenji Ishikura, Hiroshi Hataya, Masataka Honda

30.04.2024 | Original Article

Furosemide stress test to predict acute kidney injury progression in critically ill children

Acute kidney injury (AKI) is common in critically ill children, with 27% of patients developing AKI within 7 days of intensive care unit (ICU) admission [ 1 ]. Along with a stepwise increase in mortality with increasing severity of AKI, there is …

verfasst von:: Sudarsan Krishnasamy, Aditi Sinha, Rakesh Lodha, Jhuma Sankar, Mohamad Tarik, Lakshmy Ramakrishnan, Arvind Bagga, Pankaj Hari

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