Graefe's Archive for Clinical and Experimental Ophthalmology OnlineFirst articles

Open Access 24.05.2024 | Retinal Disorders

Quantitative assessment of intervortex anastomosis in central serous chorioretinopathy and fellow eyes: Does the size of anastomotic vessels matter for the diagnosis?

The term "pachychoroid" is defined as choroidal thickening with dilatation of the external choroidal vessels [ 1 ]. The vascular anatomy and physiology of the choroidal vascular system are altered in pachychoroidal conditions [ 2 ]. Numerous …

verfasst von:: Sibel Demirel, Rabia Eroğlu Ayaz, Özge Yanık, Figen Batıoğlu, Emin Özmert, Claudio Iovino, Jay Chhablani

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23.05.2024 | Inflammatory Disorders

Subclinical choroidal involvement in Systemic Lupus Erythematosus

Systemic lupus erythematosus (SLE) is a chronic, systemic, autoimmune connective tissue disease [ 1 ] with a multifactorial and complex pathogenesis that can affect the vasculature in several organs. This condition can induce vasculitis and an …

verfasst von:: André Ferreira, Luísa Viveiros, Raquel Faria, Ana Carolina Abreu, Daniela Santos, Maria João Furtado, Miguel Lume, José P. Andrade, Pedro Menéres

Open Access 21.05.2024 | Glaucoma

Intermediate-term impact on corneal endothelial cells and efficacy of Preserflo MicroShunt implantation in patients with open-angle glaucoma – a prospective study over two years

Intraocular pressure (IOP) is the only modifiable risk factor of glaucoma progression [ 1 ]. When medical treatment with IOP-lowering eye drops is either insufficient or not possible due to adherence issues, surgery is necessary to prevent …

verfasst von:: Caroline J. Gassel, Daniel A. Wenzel, Emil Nasyrov, Torsten Strasser, Bogomil Voykov

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Open Access 21.05.2024 | Retinal Disorders

The impact of Vitreo-Macular interface abnormalities on the response to Anti-VEGF therapy for centre involving diabetic macular oedema

VMIA has been reported to be present on SD-OCT in 43% of patients with CIDME [ 1 ]. The influence of Vitreomacular Interface Abnormalities (VMIA) such as Epiretinal Membrane (ERM) and/or vitreomacular traction (VMT) on the response of patients with …

verfasst von:: Matthew Maguire, Dah Laidlaw, Nigel Davies, Christopher Hammond

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18.05.2024 | Retinal Disorders

Prevalence of Age-Related Macular Degeneration in Patients with Chronic Exposure to P2X7R Inhibitors

Age-related macular degeneration (ARMD) is the leading cause of blindness in the elderly in developed countries [ 1 ]. It is typically classified in two forms, dry characterized by drusen and retinal pigment epithelial abnormalities with …

verfasst von:: Kwang Min Woo, M. Abdallah Mahrous, Donald J. D’Amico, Szilard Kiss, Kyle D. Kovacs

18.05.2024 | Brief Communication

Phototherapeutic keratectomy for corneal epithelial-stromal dystrophies in pediatric patients

Corneal dystrophies may develop gradually from early onset in childhood and persist for years to decades. Visual impairment or repeated ocular irritations caused by corneal dystrophies severely affect the quality of life. Although various surgical …

verfasst von:: Min Chen, Ping Lin, Dewei Li, Le Tian

18.05.2024 | Correction

Correction: Effects of cycloplegia on crystalline lens morphology and location in acute acquired concomitant esotropia

verfasst von:: Weibin Chen, Jiawen Liu, Wei Dai, Jie Hao, Jiayu Chen, Jing Fu

17.05.2024 | Cataract

Accuracy of 14 intraocular lens power calculation formulas in extremely long eyes

Currently, high myopia is a significant global eye health issue and the incidence is increasing [ 1 , 2 ]. It can cause some complications such as nuclear and posterior subcapsular cataract formation, vitreous degeneration, and posterior staphyloma …

verfasst von:: Xinxin Li, Chunyuan Song, Yong Wang, Jing Wang, Qiongyan Tang, Zheming Wu, Yanwen Zhou, Juan Sun, Yanhong Jia, Zhenlin Lin, Shaowei Li

17.05.2024 | Retinal Disorders

Title – Long term outcomes of vitrectomy and ERM peel: Can pre-operative metamorphopsia measured using the D-Chart help improve surgical candidate selection?

Epiretinal membranes (ERMs) are transparent, avascular proliferations of myofibroblastic cells that develop on or above the retinal surface [ 1 ]. Their reported incidence is 13.9% in the general population, but this varies based on study …

verfasst von:: James E. Hazelwood, Kim Ah-See, Su Ling Young, Harry G. B. Bennett, Ashraf Khan, Colin R. Goudie

17.05.2024 | Retinal Disorders

Five-year outcomes of treat and extend regimen using intravitreal aflibercept injection for treatment-naïve age-related macular degeneration

Neovascular age-related macular degeneration (nAMD) is the leading cause of severe vision loss in older individuals [ 1 , 2 ]. Intravitreal injection of anti-vascular endothelial growth factor (VEGF) agents significantly improves the visual …

verfasst von:: Hikaru Ota, Keiko Kataoka, Keiko Asai, Jun Takeuchi, Yuyako Nakano, Koichi Nakamura, Takahito Todoroki, Koji M Nishiguchi

17.05.2024 | Cataract

Accuracy of 10 MHz ultrasonography for evaluation of posterior lens capsule in traumatic cataract

Ocular trauma is the most common cause of monocular blindness, with about 1.6 million people worldwide becoming blind due to ocular trauma [ 1 ]. Traumatic cataract is a significant cause of visual loss in ocular trauma. Luckily, the blindness and …

verfasst von:: Xixuan Ke, Cuilian Li, Liyu Lin, Yuqiang Huang, Honghe Xia, Chuang Jin, Tingkun Shi, Qi Zhang, Xulong Liao, Haoyu Chen

16.05.2024 | Cataract

A Brillouin microscopy analysis of the crystalline lenses of Chinese adults with myopia

To evaluate lenticular biomechanical and geometric parameters in Chinese adults with myopia and identify relevant factors using Brillouin microscopy (BM) and Pentacam. The biomechanical and geometric properties of the ocular lenses of Chinese …

verfasst von:: Yong Ma, Jian Cao, Yanze Yu, Teruko Fukuyama, Yongle Bao, Xuan Ding, Lingling Niu, Xingtao Zhou, Jing Zhao

16.05.2024 | Brief Communication

The impact of image resolution on diagnostic accuracy using fractal dimension in identifying diabetic retinopathy, glaucoma, and age-related macular degeneration

During the preparation of this work the authors used ChatGPT 4.0 in order to improve the manuscript's readability and language. After using this service, the authors reviewed and edited the content as needed and take full responsibility for the …

verfasst von:: Mohd Zulfaezal Che Azemin, Mohd Izzuddin Mohd Tamrin, Firdaus Yusof, Adzura Salam

Open Access 15.05.2024 | Neurophthalmology

Evaluation and management of nonarteritic anterior ischemic optic neuropathy: a national survey

Nonarteritic anterior ischemic optic neuropathy (NAION) is the most prevalent acute optic neuropathy affecting middle-aged and older individuals [ 1 , 2 ]. Typical NAION manifests as a sudden, mostly painless monocular visual loss, often noticed …

verfasst von:: Omer Y. Bialer, Hadas Stiebel-Kalish

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15.05.2024 | Retinal Disorders

Choroidal arterial abnormality in central serous chorioretinopathy

The current consensus on the pathogenesis of central serous chorioretinopathy (CSC) is venous overload from dysregulated blood flow and outflow obstruction due to scleral thickening [ 1 – 9 ]. Unlike the evidence consistently reported for venous …

verfasst von:: Raimo Tuuminen, Sohee Jeon

14.05.2024 | Glaucoma

Choroidal thickness in juvenile open angle glaucoma: insights from a south asian case–control study

Juvenile open angle glaucoma (JOAG) is a rare disorder diagnosed between the ages of 3 and 40 years [ 1 – 3 ]. It is believed to occur as a result of the immaturity of outflow pathways (angle dysgenesis) and is usually inherited as an autosomal …

verfasst von:: Sana Nadeem

14.05.2024 | Brief Communication

Retinal metastasis from systemic carcinoma: clinical, multimodal imaging, and pathological characteristics from a multicenter case series

verfasst von:: Ching-Lung Chen, Wei-Chun Chan, Yi-Chun Chen, Yung-Ray Hsu

13.05.2024 | Letter to the Editor (by invitation)

Response to letter to the editor Re: comment on “Comparison of functional and morphologic changes between brolucizumab and faricimab in neovascular age-related macular degeneration”

verfasst von:: Maiko Maruyama-Inoue, Jacob Yuhang Chin, Kazuaki Kadonosono

Open Access 09.05.2024 | Cornea

Real-world insights and outcomes related to ciclosporin A 0.1% cationic emulsion for the long-term treatment of dry eye disease in Germany: Country-level sub-analysis of the PERSPECTIVE study

Dry eye disease (DED), also known as keratoconjunctivitis sicca, is a multifactorial, complex, and chronic ocular condition, requiring long-term treatment, which may be challenging to diagnose and treat in clinical practice [ 1 – 6 ]. The condition …

verfasst von:: Ines Lanzl, Christoph M E Deuter, Katrin Lorenz, Gerd Geerling, on behalf of the PERSPECTIVE German study group

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09.05.2024 | Retinal Disorders

Three-year outcome of photodynamic therapy combined with VEGF inhibitor for pachychoroid neovasculopathy

Pachychoroid is a phenotype characterized by attenuation of the choriocapillaris overlying dilated choroidal veins, and associated with progressive retinal pigment epithelium dysfunction and neovascularization [ 1 ]. Pachychoroid spectrum diseases …

verfasst von:: Yoko Nomura, Shuichiro Aoki, Kohdai Kitamoto, Kohei Ueda, Keiko Azuma, Tatsuya Inoue, Ryo Obata

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