Annals of Hematology OnlineFirst articles

Open Access 24.05.2024 | Case Report

Blinatumomab-induced macrophage activating syndrome (MAS) in adult with B-cell acute lymphoblastic leukemia (B-ALL)

Blinatumomab as a single agent has demonstrated superiority over salvage chemotherapy in patients with relapsed and refractory B-cell acute lymphoblastic leukemia (B-ALL), with manageable safety and efficacy. Though known to have anticipated drug …

verfasst von:: Adam Braun, Salman Otoukesh, Jose Tinajero, Guido Marcucci, Ibrahim Aldoss

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23.05.2024 | Case Report

Acute myeloid leukemia with paraneoplastic pemphigus successfully treated with a personalized antileukemic and immunosuppressive strategy

Bullous pemphigoid (BP) is a rare blistering disease often considered a primary sign of a paraneoplastic syndrome. Retrospective studies have established its link with hematological malignancies, particularly lymphoproliferative disorders. Here …

verfasst von:: Francesca Romana Iovene, Enrico Santinelli, Daniele Armiento, Chiara Sarlo, Chiara Bancone, Lorena Silvestri, Sabrina Erculei, Maria Grazia Sanhust, Antonio Cristiano, Emiliano Fabiani, Mariadomenica Divona, Camilla Page, Giovanni Di Zenzo, Maria Cantonetti, Luigi Rigacci

Open Access 23.05.2024 | Research

Flow-cytometry Assessment of DNA content and Immunophenotyping of Immune-cells in Lymph-node-specimens as a Potential Diagnostic Signature of Aggressiveness in B-Non-Hodgkin Lymphomas

Flow-cytometry (FC) is a powerful tool that can assist in lymphoma diagnosis in lymph node (LN) specimens. Although lymphoma diagnosis and classification are mainly based on tumor cell characteristics, surrounding cells are less employed in this …

verfasst von:: David Azoulay, Tal Tapuchi, Ohad Ronen, Luiza Akria, Hector I. Cohen, Celia Surio, Svetlana Rodin Chepa, Elizabeth Eshel, Moran Zarfati, Galia Stemer, Netanel A. Horowitz

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Open Access 22.05.2024 | Research

A preliminary study of roxadustat in the treatment of aplastic anemia patients with inadequate erythroid responses

Some aplastic anemia(AA) patients only have partial hematological responses after immunosuppressive therapy. Failure to achieve complete normalization of blood counts, particularly hemoglobin, will reduce their quality of life. This open-label …

verfasst von:: Yimeng Shi, Yufei Zhao, Weiru Liang, Baohang Zhang, Rui Kang, Wenrui Yang, Xin Zhao, Fengkui Zhang

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21.05.2024 | Research

The effectiveness of the doxorubicin-etoposide-methylprednisolone regimen for adult HLH secondary to rheumatic disease

To investigate the efficacy of the doxorubicin-etoposide-methylprednisolone, DEP) regimen as an effective treatment for adult Hemophagocytic Lymphohistiocytosis secondary to rheumatic disease and analyze prognosis in these patients. Fifty-eight …

verfasst von:: Dongfei Yin, Jingshi Wang, Zhao Wang

Open Access 21.05.2024 | Research

Real-life use of ropeg-interferon α2b in polycythemia vera: patient selection and clinical outcomes

Ropeginterferon-alfa2b (ropegIFNα2b) is a long-acting IFN formulation with broad FDA/EMA approval as a therapy of polycythemia vera (PV) with no symptomatic splenomegaly. There is currently lack of information on the real-world patient selection …

verfasst von:: Francesca Palandri, F. Branzanti, M. Venturi, A. Dedola, G. Fontana, M. Loffredo, A. Patuelli, E. Ottaviani, M. Bersani, M. Reta, O. Addimanda, V. Vicennati, N. Vianelli, M. Cavo

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Open Access 20.05.2024 | Research

Haemoglobinopathies and other rare anemias in Spain: ten years of a nationwide registry (REHem-AR)

REHem-AR was created in 2013. The progressive implementation of neonatal screening for haemoglobinopathies in Spanish autonomous communities where the registry had not been implemented, as well as the addition of new centres during this period …

verfasst von:: José Manuel Marco Sánchez, Eduardo Jesús Bardón Cancho, David Benéitez, Salvador Payán-Pernía, Anna Collado Gimbert, Anna Ruiz-Llobet, José Antonio Salinas, Elena Sebastián, Bienvenida Argilés, Mar Bermúdez, María Ángeles Vázquez, María José Ortega, Montserrat López Rubio, Ainhoa Gondra, José Javier Uriz, Marta Morado, María Teresa Coll, Mónica López Duarte, María Baro, Áurea Cervera, Valle Recasens, Carmen García Blanes, María Pozo del Carcavilla, María Tallon, Ana González Espín, Filip Camil Olteanu Olteanu, Pablo González, María Mar del Mañú Pereira, Elena Cela

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Open Access 20.05.2024 | Review Article

Neurological involvement in hematopoietic stem cell transplantation-associated thrombotic microangiopathy

Transplantation-associated thrombotic microangiopathy (TA-TMA) is a well-recognized serious complication of hematopoietic stem cell transplantation (HSCT). The understanding of TA-TMA pathophysiology has expanded in recent years. Dysregulation of …

verfasst von:: Wanying Liu, Xiaojian Zhu, Yi Xiao

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18.05.2024 | Research

STK10 mutations block erythropoiesis in acquired pure red cell aplasia via impairing ribosome biogenesis

Acquired pure red cell aplasia (PRCA) is anemia associated with the absence of erythroblasts and is characterized by persistent and easy recurrence. However, the underlying mechanisms of acquired PRCA remain obscure, and the role of gene mutations …

verfasst von:: Jichun Yang, Xiaofeng Shi, Xinyao Liu, Xinrui Qiao, Xun Zhou, Hongmin Li, Yali Du, Miao Chen, Dongdong Fang, Bing Han, Zhangbiao Long

18.05.2024 | Research

Clinical characteristics and prognosis of patients with newly diagnosed primary central nervous system lymphoma: a multicentre retrospective analysis

Bruton’s tyrosine kinase inhibitors (BTKi) exhibit superior efficacy in relapsed/refractory primary central nervous system lymphoma (PCNSL), but few studies have evaluated patients with newly diagnosed PCNSL, and even fewer studies have evaluated …

verfasst von:: Si-Jun Bai, Jian-Xia He, Yuan-Jun Zheng, Ye Geng, Yi-Nan Gao, Cai-Xia Zhang, Ya-Ru Wang, Li-Yuan Qin, Wen-Jun Wang, Lin-Hua Yang

17.05.2024 | Original Article

Impact of cladribine, cytarabine, and G-CSF (CLAG) as a bridging therapy prior to allogeneic hematopoietic stem cell transplantation in relapsed or refractory acute myeloid leukemia

The combination of cladribine, cytarabine, and G-CSF (CLAG) has exhibited robust synergistic anti-leukemia activity as an induction therapy (IT) in acute myeloid leukemia (AML). However, the impact of CLAG as a bridging therapy (BT) administered …

verfasst von:: Tong Cui, Huiyu Li, Shiyuan Zhou, Jing Li, Qian Zhu, Wenjuan Zhu, Zaixiang Tang, Xiao Ma, Huiying Qiu, Depei Wu, Xiaojin Wu

16.05.2024 | Research

Significance of absolute neutrophil count before allogeneic hematopoietic stem cell transplantation in adult patients with aplastic anemia

The impact of absolute neutrophil count (ANC) before allogenic hematopoietic stem cell transplantation (HSCT) on the outcomes for patients with aplastic anemia (AA) remains unclear. We retrospectively evaluated the relationship between ANC before …

verfasst von:: Yukinori Nakamura, Yoshitaka Zaimoku, Hiroki Yamaguchi, Hirohito Yamazaki, Minoru Kanaya, Naoyuki Uchida, Noriko Doki, Masatoshi Sakurai, Nobuhiro Hiramoto, Shinichi Kako, Makoto Onizuka, Koichi Onodera, Yumiko Maruyama, Hiroyuki Ohigashi, Tetsuya Nishida, Satoshi Yoshihara, Ken-ichi Matsuoka, Tetsuya Eto, Yoshinobu Kanda, Takahiro Fukuda, Yoshiko Atsuta, Yasushi Onishi

15.05.2024 | Case Report

Treatment of primary cardiac diffuse large B-cell lymphoma involving the coronary sinus with R-EPOCH: a case report and literature review

Primary cardiac lymphomas (PCLs) are a rare clinical entity, in which treatment guidelines remain to be established. Rituximab, etoposide, prednisone, vincristine, cyclophosphamide, and doxorubicin (R-EPOCH) has been proposed, given that it …

verfasst von:: Aryan Rezvani, Shilpan Shah

14.05.2024 | Research

Genetic variability profiling of the p53 signaling pathway in chronic lymphocytic leukemia. Individual and combined analysis of TP53, MDM2 and NQO1 gene variants

TP53 gene disruption, including 17p13 deletion [del(17p)] and/or TP53 mutations, is a negative prognostic biomarker in chronic lymphocytic leukemia (CLL) associated with disease progression, treatment failure and shorter survival. Germline …

verfasst von:: María Belén Fontecha, María Del Rosario Anadón, Verónica Mercado Guzmán, Carmen Stanganelli, Camila Galvano, Fernanda Tosin, Javier Bordone, Raimundo Bezares, Cecilia Rodríguez, Viviana Heller, Irma Slavutsky, Ariela Freya Fundia

13.05.2024 | Original Article

Development and validation of an early mortality risk model for pediatric hemophagocytic lymphohistiocytosis: a comparison with HScore, PELOD-2, P-MODS, and pSOFA

There has been no severity evaluation model for pediatric patients with hemophagocytic lymphohistiocytosis (HLH) that uses readily available parameters. This study aimed to develop a novel model for predicting the early mortality risk in pediatric …

verfasst von:: Zhexuan Tang, Desheng Zhu, Xun Li, Haipeng Yan, Ting Luo, Longlong Xie, Yufan Yang, Minghui Tang, Xuedan Jiang, Jiaotian Huang, Xinping Zhang, Lifang Zhou, Yefei Lei, Zhenghui Xiao, Xiulan Lu

12.05.2024 | Original Research

Comprehensive procedure for injecting Evusheld® for hematological diseases in a single institute

Tixagevimab and cilgavimab (EVA, Evusheld®), monoclonal antibody combination treatments, consisted of two neutralizing antibodies against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). EVA showed prophylactic and therapeutic effects …

verfasst von:: Osamu Imataki, Shunsuke Yoshida, Tomoya Ishida, Makiko Uemura, Haruyuki Fujita, Norimitsu Kadowaki

11.05.2024 | Research

Optimization of immune checkpoint inhibitor treatment planning for relapsed or refractory extranodal NK/T cell lymphoma

Pembrolizumab (anti-programmed cell death-ligand 1 inhibitor) is a promising salvage therapeutic option for relapsed/refractory extranodal NK/T-cell lymphoma (R/R ENKTL). However, the appropriate duration of pembrolizumab use in R/R ENKTL patients …

verfasst von:: Sang Eun Yoon, Hyungwoo Cho, Philipp Berning, Junhun Cho, Hyun-Young Kim, Dok Hyun Yoon, Norbert Schmit, Seok Jin Kim, Won Seog Kim

Open Access 11.05.2024 | Letter to the Editor

Plasmapheresis effectively abrogates severe liver toxicity of pegaspargase in a patient with acute lymphoblastic leukemia

verfasst von:: Markus Tölle, Nicola Gökbuget, Stefan Habringer, Ulrich Keller, Stefan Schwartz

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10.05.2024 | Case Report

DNT cells mediate resistance to CAR-T cells therapy in a pediatric patient with relapsed and refractory B-ALL

Chimeric antigen receptor T (CAR-T) cells therapy is a milestone achievement in the immunotherapy of relapsed and refractory (R/R) B cell acute lymphoblastic leukemia (B-ALL). However, some patients treated with CAR-T cells do not achieve complete …

verfasst von:: Ruotong Chen, Qianshan Tao, Fan Wu, Zhimin Zhai, Yuchen Jiang, Caixian Xu, Huiping Wang

09.05.2024 | Original Article

Clinical prognostic value of different NPM1 mutations in acute myeloid leukemia patients

Background: Acute myeloid leukemia (AML) patients with various nucleophosmin 1 (NPM1) mutations are controversial in the prognosis. This study aimed to investigate the prognosis of patients according to types of NPM1 mutations (NPM1mut). Methods: …

verfasst von:: Yu Shi, Xiao Chen, Huimin Jin, Liying Zhu, Ming Hong, Yu Zhu, Yujie Wu, Hairong Qiu, Yan Wang, Qian Sun, Hui Jin, Jianyong Li, Sixuan Qian, Chun Qiao

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