Endocrine OnlineFirst articles

27.05.2024 | Meta- Analysis

Value of radiofrequency ablation for treating locally recurrent thyroid cancer: a systematic review and meta-analysis for 2-year follow-up

Thyroid cancer has been the most common endocrine malignancy in recent decades, the incidence of thyroid cancer increased from 7.25 per 100,000 person-years in 2000 to 13.48 per 100,000 person-years in 2018 in United States [ 1 ]. Most thyroid …

verfasst von:: Zhen Yang, Mingbo Zhang, Lin Yan, Jing Xiao, Yingying Li, Xinyang Li, Yukun Luo

27.05.2024 | Original Article

Muscle function, exercise capacity, physical activity level and cardiovascular disease risk factor knowledge in patients with prolactinoma

Prolactinoma is the most commonly observed type of secretory pituitary adenoma [ 1 ]. High prolactin (PRL) levels increase sympathetic tone and mediate chronotropic responses and vasoconstrictive effects, which have been associated with increased …

verfasst von:: Ayşegül Erkoç, İmdat Eroğlu, Tomris Erbas, Ebru Calik Kutukcu

Open Access 27.05.2024 | Original Article

Small RNA sequencing reveals snoRNAs and piRNA-019825 as novel players in diabetic kidney disease

Diabetic kidney disease (DKD) is one of the most common complications in type 2 diabetes. Nonetheless, while some develop complications early in the disease, others will never. The mechanisms underlying DKD are not fully understood though [ 1 ].

verfasst von:: L. M. ’t Hart, J. A. de Klerk, G. A. Bouland, J. H. D. Peerlings, M. T. Blom, S. J. Cramer, R. Bijkerk, J. W. J. Beulens, R. C. Slieker

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27.05.2024 | Brief Report

Primary resistance to selpercatinib in a patient with advanced medullary thyroid cancer

Selpercatinib, a selective RET kinase inhibitor, has demonstrated remarkable efficacy in treating patients with advanced medullary (MTC) and differentiated thyroid cancer with RET alterations. Primary resistance to selpercatinib is a very uncommon …

verfasst von:: Fabian Pitoia, Pierpaolo Trimboli, Erika Abelleira

24.05.2024 | Correction

Correction to: Androgen-induced upregulation of CFTR in pancreatic β-cell contributes to hyperinsulinemia in PCOS model

verfasst von:: Mengzhu Sun, Yong Wu, Chun Yuan, Jingya Lyu, Xinyi Zhao, Ye Chun Ruan, Jinghui Guo, Hui Chen, Wen Qing Huang

Open Access 24.05.2024 | Original Article

Quality of life, diabetes-related stress and treatment satisfaction are correlated with glycemia risk index (GRI), time in range and hypoglycemia/hyperglycemia components in type 1 diabetes

Data provided by continuous glucose monitoring (CGM) systems have become the preferred form of blood glucose monitoring to achieve adequate control in patients with type 1 diabetes (T1D) [ 1 – 3 ]. It is well known that the use of these devices …

verfasst von:: Gonzalo Díaz-Soto, Paloma Pérez-López, Pablo Férnandez-Velasco, Pilar Bahillo-Curieses, María de la O Nieto de la Marca, Rebeca Jimenez, Daniel de Luis

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Open Access 23.05.2024 | Original Article

Effects of metformin on the glucose regulation, lipid levels and gut microbiota in high-fat diet with streptozotocin induced type 2 diabetes mellitus rats

The recent rise in high-salt, high-fat, and high-sugar diets has led to a gradual annual increase in the incidence of diabetes, posing a threat to human health [ 1 ]. Type 2 diabetes mellitus (T2DM) accounts for 95% of all diabetes cases. The …

verfasst von:: Xuan Zhou, Jian Zhou, Qingfeng Ban, Mei Zhang, Bo Ban

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23.05.2024 | Original Article

Association between the triglyceride-glucose index and thyroid disorders: a cross-sectional survey and Mendelian randomization analysis

Insulin resistance refers to the insensitivity of tissues (such as muscle, fat, and liver) to insulin [ 1 ]. Insulin resistance is considered a key predictor of hypertension, hypertriglyceridemia, abdominal obesity and impaired glucose tolerance [ …

verfasst von:: Chenyu Zhang, Haoyu Wang, Yongze Li, Xichang Wang, Yutong Han, Xiaotong Gao, Yaxin Lai, Chuyuan Wang, Weiping Teng, Zhongyan Shan

Open Access 22.05.2024 | Original Paper

Cardiac magnetic resonance reveals biventricular impairment in Cushing’s syndrome: a multicentre case-control study

Cushing’s syndrome (CS), or chronic hypercortisolism, is associated with increased mortality mostly due to cardiovascular disease [ 1 , 2 ], with infectious diseases and coexisting comorbidities also playing a role [ 1 – 9 ]. Older age at …

verfasst von:: Tiziana Feola, Alessia Cozzolino, Dario De Alcubierre, Riccardo Pofi, Nicola Galea, Carlo Catalano, Chiara Simeoli, Nicola Di Paola, Federica Campolo, Rosario Pivonello, Andrea M. Isidori, Elisa Giannetta

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21.05.2024 | Original Article

Ten years’ real-life experience on the use of multikinase inhibitors in patients with advanced differentiated thyroid cancer

Up to 15% of differentiated thyroid cancer (DTC) patients exhibit an aggressive disease, resulting in the development of distant metastases [ 1 ]. Approximately two-thirds of these patients do not respond to radioactive iodine (RAI) treatment which …

verfasst von:: Fernando Jerkovich, Soledad Capalbo, Erika Abelleira, Fabián Pitoia

21.05.2024 | Original Article

C-reactive protein to albumin ratio and risk of incident metabolic syndrome in community-dwelling adults: longitudinal findings over a 12-year follow-up period

Metabolic syndrome (MetS) is a cluster of cardiometabolic abnormalities, including visceral obesity, high blood pressure, glucose intolerance, and atherogenic dyslipidemia. Individuals with MetS tend to be more susceptible to cardiovascular …

verfasst von:: Taekyeong Lim, Yong-Jae Lee

21.05.2024 | Original Article

Assessing blood sugar measures for predicting new-onset diabetes and cardiovascular disease in community-dwelling adults

Diabetes mellitus (DM) is a growing global health concern characterized by chronic hyperglycemia resulting from defects in insulin secretion or action [ 1 ]. According to the 2021 Diabetes Fact Sheet in Korea, the overall prevalence of DM among …

verfasst von:: Jung-Hwan Kim, Yaeji Lee, Chung-Mo Nam, Yu-Jin Kwon, Ji-Won Lee

21.05.2024 | Review

Hypogonadism and nonalcoholic fatty liver disease

Nonalcoholic fatty liver disease (NAFLD), recently proposed to be renamed to metabolic dysfunction-associated steatotic liver disease (MASLD), is a major global public health concern, affecting approximately 25–30% of the adult population and …

verfasst von:: Kasiani Papadimitriou, Athanasios C. Mousiolis, Gesthimani Mintziori, Christina Tarenidou, Stergios A. Polyzos, Dimitrios G. Goulis

Open Access 20.05.2024 | Mini Review

Management of low-risk papillary thyroid cancer. Minimally-invasive treatments dictate a further paradigm shift?

The diagnosis of papillary thyroid carcinoma (PTC) has become more frequent during the last decades due to the widespread availability of neck imaging techniques, routine use of ultrasound (US)-guided fine needle aspiration biopsy (FNA), and …

verfasst von:: E. Papini, R. Guglielmi, R. Novizio, A. Pontecorvi, C. Durante

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20.05.2024 | Original Article

Impact of thyroid carcinoma invasion of recurrent laryngeal nerve on cervical lymph node metastasis

The incidence of thyroid carcinoma has increased rapidly in recent years. Differentiated thyroid cancer, especially papillary carcinoma, has a favorable prognosis with low mortality rates as most tumors belong to the low-risk group [ 1 ]. However …

verfasst von:: Feng Zhu, YiBin Shen, LiXian Zhu, LinHui Chen, FuQiang Li, XiaoJun Xie, YiJun Wu

18.05.2024 | Original Article

Metformin-induced changes of the gut microbiota in patients with type 2 diabetes mellitus: results from a prospective cohort study

Type 2 diabetes mellitus (T2DM) is a prevalent chronic disease associated with life-threatening complications, disabilities, and substantial financial burdens, concurrently reducing life expectancy [ 1 ]. This disorder, marked by insulin resistance …

verfasst von:: Yuting Gao, Tianyi Zhao, Na Lv, Shixuan Liu, Tao Yuan, Yong Fu, Weigang Zhao, Baoli Zhu

18.05.2024 | Original Article

Hypogonadism as a consequence of craniopharyngioma in female patients: comparison of childhood and adult onset and effects of estrogen replacement therapy

Craniopharyngioma (CP) is a rare solid epithelial tumor localized in the sellar and/or suprasellar region [ 1 ]. Ninety-four per cent of the tumors had an extrasellar component and 23% of them were associated with hydrocephalus [ 2 ]. Therefore …

verfasst von:: Irena Ilovayskaya, Vita Zektser

18.05.2024 | Original Article

Clinical and functional characterization of a novel KCNJ11 (c.101G > A, p.R34H) mutation associated with maturity-onset diabetes mellitus of the young type 13

In 2012, based on whole-exome sequencing, the Illumina-Golden Gate assay, and linkage analysis techniques, Bonnefond et al. [ 1 ] reported that the KCNJ11 gene was identified and reported as a new MODY-causing gene isoform for the first time. Since …

verfasst von:: Xiaoyu Lv, Jing Gao, Jingwen Yang, Ying Zou, Jun Chen, Yujing Sun, Jia Song, Yiran Liu, Liming Wang, Longqing Xia, Shijia Yu, Zichun Wei, Li Chen, Xinguo Hou

18.05.2024 | Original Article

Positive association of the anti-aging protein α-Klotho with insulin resistance and its inverse L-shaped relationship with glycaemic control in the middle-aged and elderly population

In light of the global epidemics of obesity and diabetes, which are particularly prevalent in developed countries and many emerging regions, insulin resistance has garnered increasing attention as a pivotal etiological factor. Insulin resistance …

verfasst von:: Kai Wang, Jianing Liu

18.05.2024 | Mini Review

Clinical and therapeutic implications of cavernous sinus invasion in pituitary adenomas

Invasion of the cavernous sinus by pituitary adenomas impedes complete surgical resection, compromises biochemical remission, and increases the risk of further tumor recurrence. Accurate preoperative MRI-based diagnosis or intraoperative direct …

verfasst von:: Etienne Lefevre, Fanny Chasseloup, Mirella Hage, Philippe Chanson, Michael Buchfelder, Peter Kamenický

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